Detailed information of TA system TA228007

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 1228111..1228682
• Replicon: chromosome
• Accession: NZ_CP089309
• Organism: Thiocapsa bogorovii strain BBS

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LT988_RS05520
• Protein ID: WP_232409226.1
• Coordinates: 1228111..1228485 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: LT988_RS05525
• Protein ID: WP_232409227.1
• Coordinates: 1228482..1228682 (-)
• Length: 67 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LT988_RS05495 (LT988_05495)	1223190..1223492	-	303	WP_232409221.1	HigA family addiction module antitoxin	-
LT988_RS05500 (LT988_05500)	1223505..1223783	-	279	WP_232409222.1	type II toxin-antitoxin system RelE/ParE family toxin	-
LT988_RS05505 (LT988_05505)	1223809..1224462	-	654	WP_232409223.1	DUF4276 family protein	-
LT988_RS05510 (LT988_05510)	1224459..1225514	-	1056	WP_232409224.1	AAA family ATPase	-
LT988_RS05515 (LT988_05515)	1225550..1228060	-	2511	WP_232409225.1	transposase	-
LT988_RS05520 (LT988_05520)	1228111..1228485	-	375	WP_232409226.1	type II toxin-antitoxin system VapC family toxin	Toxin
LT988_RS05525 (LT988_05525)	1228482..1228682	-	201	WP_232409227.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
LT988_RS05530 (LT988_05530)	1228847..1229026	-	180	WP_232409228.1	hypothetical protein	-
LT988_RS05535 (LT988_05535)	1229023..1229349	-	327	WP_232409229.1	type II toxin-antitoxin system PemK/MazF family toxin	-
LT988_RS05540 (LT988_05540)	1229346..1229570	-	225	WP_232409230.1	antitoxin MazE family protein	-
LT988_RS05545 (LT988_05545)	1229820..1232549	-	2730	WP_232409231.1	BREX system P-loop protein BrxC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1232659..1234053	1394

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-46)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13618.80 Da
• Isoelectric Point: 10.3625

>T228007 WP_232409226.1 NZ_CP089309:c1228485-1228111 [Thiocapsa bogorovii]
VIPVDTSVWVDHLRSGDAPLAARLEAASVAMRPMVLGELVCGNLKDRQTLLALWRNLPQLPAATDAEALFFLVRNRLLGR
GIGYNGVHLLASVSLHARARLWTRDRRLRATAEQLGLAHPEPDA

Nucleotide

• Length: 375 bp

>T228007 NZ_CP123255:c604109-603645 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAACCCCATTGA

Antitoxin

Protein

• Length: 67 a.a.
• Molecular weight: 7384.47 Da
• Isoelectric Point: 10.6625

>AT228007 WP_232409227.1 NZ_CP089309:c1228682-1228482 [Thiocapsa bogorovii]
MRTTLNIDDDLLQRARDLSGMQEKTALIREGLKALIERESARRLARLGGSEPGLEPIPRRRVETGG

Nucleotide

• Length: 201 bp

>AT228007 NZ_CP123255:c604444-604109 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA