227990

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 5477822..5478363 Replicon chromosome
Accession NZ_CP089301
Organism Novosphingobium kaempferiae strain Sx8-5

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LO787_RS25030 Protein ID WP_232493667.1
Coordinates 5477822..5478145 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag LO787_RS25035 Protein ID WP_232493668.1
Coordinates 5478142..5478363 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO787_RS25000 5473440..5473742 + 303 WP_232493663.1 type II toxin-antitoxin system HigB family toxin -
LO787_RS25005 5473760..5474125 + 366 WP_232493664.1 transcriptional regulator -
LO787_RS25010 5474213..5475100 + 888 WP_232493665.1 replication initiator protein A -
LO787_RS25015 5475290..5475865 + 576 WP_232493666.1 dTDP-4-dehydrorhamnose 3,5-epimerase -
LO787_RS25020 5475891..5476769 + 879 WP_232496416.1 dTDP-4-dehydrorhamnose reductase -
LO787_RS25025 5476784..5477779 - 996 WP_232496417.1 phytanoyl-CoA dioxygenase family protein -
LO787_RS25030 5477822..5478145 - 324 WP_232493667.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LO787_RS25035 5478142..5478363 - 222 WP_232493668.1 antitoxin MazE family protein Antitoxin
LO787_RS25040 5478441..5479268 - 828 WP_232493669.1 3-deoxy-8-phosphooctulonate synthase -
LO787_RS25045 5479460..5480446 + 987 WP_232493670.1 KpsF/GutQ family sugar-phosphate isomerase -
LO787_RS25050 5480460..5480849 - 390 WP_232493671.1 type II toxin-antitoxin system VapC family toxin -
LO787_RS25055 5480846..5481091 - 246 WP_232493672.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
LO787_RS25060 5481217..5482035 + 819 WP_232493673.1 3-deoxy-manno-octulosonate cytidylyltransferase -
LO787_RS25065 5482049..5482636 + 588 WP_232493674.1 histidine phosphatase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-103)

Antitoxin

Antitoxin MazE-like

(7-70)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11293.20 Da        Isoelectric Point: 10.1781

>T227990 WP_232493667.1 NZ_CP089301:c5478145-5477822 [Novosphingobium kaempferiae]
VKRGDLVTIAAPGDFGKPRPALVVQSDRFDATGTLTVLLLSGTPVDAPLIRVPVAPTPDNGLRKPSQVMVDKAMSVKRER
IGATIGQLDAETMLSVTRSLAVFLDIA

Download         Length: 324 bp

>T227990 NZ_CP123245:84382-85707 [Escherichia coli]
ATGAGCCGGAAACAGCAACGTCTGGTAATTTGGATGAACGGCATCAAAGTCGGGTACTGGGAAAAAAGCAAAGGGGTAGA
CAGCTTAGAATACCTTCCTGAATGGGTTGCTGACGAACAGGGAAGGCCGCTGTCATTGTCCCTTCCTTTTACTCCCGGGA
ACCAGGTCTGGCGTGGAAATGTGGTACGTGACTATTTTGATAATTTACTGCCGGACAGCGAAGGCATACGCAGACGTCTG
GCAATGCGTTACAAGGCCGATAGCCTGGAGCCTTTTGATCTGCTGACGGAGCTGGGAAAAGACTGCGTGGGCGCGATACA
GCTGCTTCATGACGGAGATGAACCCACTGATTTATATTCCGTGAAGTATCACCCGCTTACTGAATCAGAAATTGCGGCAA
CTTTGCGTAATACCACGGAGACATTGCTACCGGGCAGGCCAGAAGATAACGACGACTTACGTTTATCTATTGCCGGTGCT
CAGGAGAAAACAGCCCTACTGTGGCATGAAGATCGGTGGTGTATGCCGGAGGGTAATACACCAACGACGCATATATTCAA
GCTACCGCTCGGACTTGTGGGGAACATGAAAGCCGACATGAGCTCGTCGGTTGAAAATGAATGGCTCTGCTCGGTACTTC
TCGGCCAGTACGGGCTCCCCGTGGCAAGAACGCAGATTGCTCACTTTGAAGATCAGAAAGCGCTGGTGGTAGAACGTTTT
GACCGAAAATGGTCAGGAGACGGACAATGGATCATTCGTTTACCCCAGGAGGATATGTGTCAGGCCCTGGGCGTTTCGCC
ATTACGAAAATATCAGGCGGACGGCGGGCCAGGTATATCGGAAATTATGGAGGTTCTGAGTAATTCAGACCGTGCTGAGC
GTGACAAAGCGCAGTTTTTTATGACGCAGATAATTTTCTGGATGATGGCCGCAACAGATGGCCACGCTAAAAATTTCAGT
ATTTCTATTGGGCCACAGGGACGTTATCACCTTACACCAAACTATGATGTGTTGTCGGCATGGCCGGTGATCGGTCATGG
GAACAATCAGATATCCTGGCAGAAGTGCAAATTGGCGATGGCCGTACGTGGCAGTAGCAACTATTACCAGATATATCGAA
TACAACGACGCCACTGGATCAGGCATGGTGAGATAACCGGCCTGAGTAAACAGCAGACAGAGGCGATGATAGAGGAAATC
ATCGCCAGAACCCCAGGTGTCATTGAACGTGTTAGCGGGCTTCTTCCGGACCAGTTCCCCCAGCAGCTTGCGGAAAGTAT
TTTTGATGGAATGAGGCAGCAATGCAGGCGCCTGGCTGAGAAATGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8090.06 Da        Isoelectric Point: 4.3286

>AT227990 WP_232493668.1 NZ_CP089301:c5478363-5478142 [Novosphingobium kaempferiae]
MPAPVSERVRKRRDALRAAGLRPIQIWVPDTRRPGFAEECRRQALAVAAADTTDADLDDFLDAALVDLDAEDE

Download         Length: 222 bp

>AT227990 NZ_CP123245:84084-84377 [Escherichia coli]
ATCAATAATGATTACCCGTTAAACACGCTCAACCAGCTGCGTCCCTTGCTCATTGGTTTTCGCAAGGCGAATGGCCTGAC
GCAAAAAGACCTGTCCGAAAGGTTAGGCGTCACTCAACAGACATACTCACGTCTGGAAGCCAACCCTGCCAGTGCGAGCA
TTGAACGGCTATTCAAGGTGTTTTCCATCCTGGGCGTAAAAATCAGCTTCTCCTCGGCAACCACCTCTTCAGAGAGGAAG
CAGACGGAAGAAATGCTTAAATCAAACTCACCTGCACGACAGGAGGATTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References