227989

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PrpT-parD/ParE-CC2985
Location 5259175..5259703 Replicon chromosome
Accession NZ_CP089301
Organism Novosphingobium kaempferiae strain Sx8-5

Toxin (Protein)


Gene name PrpT Uniprot ID -
Locus tag LO787_RS23880 Protein ID WP_232493445.1
Coordinates 5259413..5259703 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag LO787_RS23875 Protein ID WP_232493444.1
Coordinates 5259175..5259420 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO787_RS23850 5254621..5256027 - 1407 WP_232493439.1 nitronate monooxygenase -
LO787_RS23855 5256058..5256813 - 756 WP_232493440.1 class I SAM-dependent methyltransferase -
LO787_RS23860 5256914..5258041 - 1128 WP_232493441.1 peptide chain release factor 2 -
LO787_RS23865 5258168..5258719 - 552 WP_232493442.1 peroxiredoxin -
LO787_RS23870 5258760..5258990 - 231 WP_232493443.1 biotin/lipoyl-containing protein -
LO787_RS23875 5259175..5259420 + 246 WP_232493444.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
LO787_RS23880 5259413..5259703 + 291 WP_232493445.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LO787_RS23885 5259700..5261124 - 1425 WP_232493446.1 acyl-CoA reductase -
LO787_RS23890 5261121..5262470 - 1350 WP_232493447.1 hypothetical protein -
LO787_RS23895 5262569..5263210 + 642 WP_232493448.1 TetR/AcrR family transcriptional regulator -
LO787_RS23900 5263266..5264507 + 1242 WP_232493449.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-91)

Antitoxin

Antitoxin ParD

(7-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11139.60 Da        Isoelectric Point: 7.4344

>T227989 WP_232493445.1 NZ_CP089301:5259413-5259703 [Novosphingobium kaempferiae]
MGEFRLSPRAQRDLETIFDHTAAEWGIAQAVRYIDLIEQACASLADAPLQSSDCSHIRPGYRKRTVERHSLYFRQTDYGV
AIMRILHDRMDAHRHV

Download         Length: 291 bp

>T227989 NZ_CP123244:c4612896-4612585 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9097.11 Da        Isoelectric Point: 6.3494

>AT227989 WP_232493444.1 NZ_CP089301:5259175-5259420 [Novosphingobium kaempferiae]
MSTVRKTITLTGQQDAWIAEQVQAGRYTNDSEAIRDLIRREQERTGEIAAIRSALIEGEQSGEPERFDFGAFKRRKIAGN
G

Download         Length: 246 bp

>AT227989 NZ_CP123244:c4612584-4612294 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References