Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 259466..260039 Replicon chromosome
Accession NZ_CP089283
Organism Helicobacter pylori strain J99 derivative isolate D1

Toxin (Protein)


Gene name relE Uniprot ID Q9ZKV4
Locus tag LUA78_RS01225 Protein ID WP_001880357.1
Coordinates 259466..259738 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID M3K213
Locus tag LUA78_RS01230 Protein ID WP_001134114.1
Coordinates 259752..260039 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUA78_RS01185 (LUA78_01185) 254664..255521 - 858 WP_000538063.1 SDR family oxidoreductase -
LUA78_RS01190 (LUA78_01190) 255661..256185 + 525 WP_001135603.1 acyl-CoA thioesterase -
LUA78_RS01195 (LUA78_01195) 256260..256562 - 303 WP_000889627.1 YafQ family addiction module toxin -
LUA78_RS01200 (LUA78_01200) 256711..258039 - 1329 WP_000867414.1 RNA-guided endonuclease TnpB family protein -
LUA78_RS01205 (LUA78_01205) 258067..258261 + 195 Protein_237 IS200/IS605-like element IS606 family transposase -
LUA78_RS01210 (LUA78_01210) 258392..258589 - 198 Protein_238 hypothetical protein -
LUA78_RS01215 (LUA78_01215) 258657..258803 - 147 WP_000820666.1 hypothetical protein -
LUA78_RS01220 (LUA78_01220) 259167..259418 - 252 WP_001134119.1 hypothetical protein -
LUA78_RS01225 (LUA78_01225) 259466..259738 - 273 WP_001880357.1 type II toxin-antitoxin system mRNA interferase toxin, HP0892 family Toxin
LUA78_RS01230 (LUA78_01230) 259752..260039 - 288 WP_001134114.1 type II toxin-antitoxin system antitoxin Antitoxin
LUA78_RS01235 (LUA78_01235) 260548..262782 - 2235 WP_234618082.1 Hop family adhesin BabA -
LUA78_RS01250 (LUA78_01250) 263885..264005 - 121 Protein_244 hydrogenase formation protein HypD -
LUA78_RS01255 (LUA78_01255) 264020..264140 - 121 Protein_245 hydrogenase formation protein HypD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 256711..258039 1328


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10484.42 Da        Isoelectric Point: 9.7463

>T227981 WP_001880357.1 NZ_CP089283:c259738-259466 [Helicobacter pylori]
MLTIETSKKFDKDLKILVKNGFDLKLLYKVVGNLATEQPLEPKYKDHPLKGALKDFRECHLKPDLLLVYQIKKQENTLFL
VRLGSHSELF

Download         Length: 273 bp

>T227981 NZ_CP123244:2411607-2412929 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CAGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTAACGTTATTACCCGAAAA
TGAAACCATAACGCGCCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGGCTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTTAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCTGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCGTTTTTGATGGGGTCCAGCGAGGCGCTTCGCGATCGTTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAAATGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTAAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11378.18 Da        Isoelectric Point: 10.4152

>AT227981 WP_001134114.1 NZ_CP089283:c260039-259752 [Helicobacter pylori]
MPNTTNKDYTKYSQKQLFNFLNSIKAKQKRALEKLKEIQTQKQRIKKALQFKALHLTENGYTIEEEREILARAKDTKNRL
CFKSIEDFKKHCENL

Download         Length: 288 bp

>AT227981 NZ_CP123244:2411341-2411607 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACACTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1W0VLH9

Antitoxin

Source ID Structure
AlphaFold DB M3K213

References