Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 254785..255304 Replicon chromosome
Accession NZ_CP089282
Organism Pseudomonas amygdali pv. loropetali strain AAC

Toxin (Protein)


Gene name relE Uniprot ID Q48Q48
Locus tag LT107_RS01125 Protein ID WP_002551445.1
Coordinates 255014..255304 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S6UWW5
Locus tag LT107_RS01120 Protein ID WP_002551444.1
Coordinates 254785..255024 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LT107_RS01095 (LT107_01095) 249884..250762 + 879 WP_004654103.1 N-carbamoylputrescine amidase -
LT107_RS01100 (LT107_01100) 250768..251874 + 1107 WP_243786931.1 agmatine deiminase -
LT107_RS01105 (LT107_01105) 252097..252330 + 234 WP_080164825.1 hypothetical protein -
LT107_RS01110 (LT107_01110) 252545..253819 + 1275 WP_004667253.1 OprD family porin -
LT107_RS01115 (LT107_01115) 253853..254347 - 495 WP_004667254.1 hypothetical protein -
LT107_RS01120 (LT107_01120) 254785..255024 + 240 WP_002551444.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LT107_RS01125 (LT107_01125) 255014..255304 + 291 WP_002551445.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LT107_RS01130 (LT107_01130) 255381..255630 + 250 Protein_224 hypothetical protein -
LT107_RS01135 (LT107_01135) 255537..255809 - 273 Protein_225 hypothetical protein -
LT107_RS01145 (LT107_01145) 256649..256888 + 240 WP_080718878.1 hypothetical protein -
LT107_RS01150 (LT107_01150) 257299..258312 + 1014 WP_054071671.1 J domain-containing protein -
LT107_RS01155 (LT107_01155) 258737..259060 + 324 WP_002555787.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-64)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11316.19 Da        Isoelectric Point: 10.2579

>T227975 WP_002551445.1 NZ_CP089282:255014-255304 [Pseudomonas amygdali pv. loropetali]
MTYNLEFDARALKEWHKLGDTVRQQLKKKLATILVAPRVEANRLHALPDCYKIKLRSSGYRLVYQVIDQEVVVFVVAVDK
REREEVYRKATDRLGR

Download         Length: 291 bp

>T227975 NZ_CP123244:287899-288174 [Escherichia coli]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAATCTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8955.34 Da        Isoelectric Point: 4.6017

>AT227975 WP_002551444.1 NZ_CP089282:254785-255024 [Pseudomonas amygdali pv. loropetali]
MASINVRIDDDLKARAYLELEKLGVTPSELLRQTLQYVAERGQLPFKTVLMTEEDEALLATVRERLAAPQRVKVSLDDL

Download         Length: 240 bp

>AT227975 NZ_CP123244:288171-288530 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G4DBS4

Antitoxin

Source ID Structure
AlphaFold DB A0A0K8M1G9

References