Detailed information of TA system TA022796

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 901529..902174
• Replicon: chromosome
• Accession: NC_010554
• Organism: Proteus mirabilis HI4320

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: B4ET86
• Locus tag: PMI_RS04015
• Protein ID: WP_004247035.1
• Coordinates: 901989..902174 (-)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: B4ET85
• Locus tag: PMI_RS04010
• Protein ID: WP_004247034.1
• Coordinates: 901529..901942 (-)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PMI_RS19415	897083..897241	-	159	WP_004247025.1	hypothetical protein	-
PMI_RS19420	897693..897869	+	177	WP_004247793.1	hypothetical protein	-
PMI_RS03985	898038..898784	-	747	WP_012367749.1	class I SAM-dependent methyltransferase	-
PMI_RS03995	899635..900213	+	579	WP_012367750.1	alpha/beta hydrolase	-
PMI_RS04000	900326..900619	-	294	Protein_795	LysE family transporter	-
PMI_RS04005	900933..901433	-	501	WP_041707083.1	response regulator	-
PMI_RS04010	901529..901942	-	414	WP_004247034.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
PMI_RS04015	901989..902174	-	186	WP_004247035.1	type II toxin-antitoxin system HicA family toxin	Toxin
PMI_RS04020	902285..903055	+	771	Protein_799	DUF1073 domain-containing protein	-
PMI_RS04025	903615..904165	-	551	Protein_800	PH domain-containing protein	-
PMI_RS04030	904229..904543	-	315	WP_012367751.1	hypothetical protein	-
PMI_RS04040	904960..906693	-	1734	WP_012367752.1	LPS biosynthesis-modulating metalloenzyme YejM	-
PMI_RS04045	906717..906944	-	228	WP_004247042.1	YejL family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 7049.30 Da
• Isoelectric Point: 10.9659

>T22796 WP_004247035.1 NC_010554:c902174-901989 [Proteus mirabilis HI4320]
MKSSELIKLLEKNGWILDRIKGSHHQFTHPDFSFVVTVPHPRKDLKKGTLNQIIKSAKLKN

Nucleotide

• Length: 186 bp

>T22796 NC_010554:c902174-901989 [Proteus mirabilis HI4320]
TTGAAAAGTTCGGAACTGATTAAGTTGTTAGAAAAAAACGGATGGATACTTGATAGAATAAAAGGAAGTCATCATCAATT
TACTCACCCTGATTTTTCTTTTGTTGTAACAGTACCGCATCCAAGAAAAGATTTAAAAAAAGGAACATTAAATCAAATTA
TTAAAAGTGCCAAACTGAAAAATTAA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15251.98 Da
• Isoelectric Point: 4.3830

>AT22796 WP_004247034.1 NC_010554:c901942-901529 [Proteus mirabilis HI4320]
MLYPAFIEIDEDGSASGWFPDIDGCIFAGDSIEEAHADARSAIDAHFELLSEKGLDIPSPKSQQEHLINSSGDYNNGIWL
LVDVDMDKYDGRAERINITLPHRLLSRIDTIVKTNPEYGSRSGFIATATRKELQKNI

Nucleotide

• Length: 414 bp

>AT22796 NC_010554:c901942-901529 [Proteus mirabilis HI4320]
ATGTTATATCCAGCCTTTATTGAAATTGATGAAGATGGTAGCGCAAGTGGCTGGTTCCCTGATATTGATGGTTGCATCTT
TGCGGGGGACAGTATTGAAGAAGCTCACGCAGATGCGAGGAGCGCTATTGATGCCCATTTTGAATTGTTAAGCGAGAAGG
GTTTAGATATCCCCTCTCCAAAATCTCAACAAGAGCATTTAATTAATTCTAGTGGTGATTACAATAATGGAATATGGCTT
TTAGTTGATGTTGATATGGATAAATACGACGGACGAGCAGAGCGTATTAATATCACATTGCCACATCGATTATTGAGTCG
CATCGATACTATCGTAAAAACAAATCCTGAATATGGGAGTCGTAGCGGATTTATTGCCACAGCAACCCGTAAAGAACTCC
AAAAGAATATTTAA

Structures

Toxin

• AlphaFold DB: B4ET86

Antitoxin

• AlphaFold DB: B4ET85