Detailed information of TA system TA022791

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 2618408..2618927
• Replicon: chromosome
• Accession: NC_010552
• Organism: Burkholderia ambifaria MC40-6

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B1Z1X1
• Locus tag: BAMMC406_RS26970
• Protein ID: WP_012367044.1
• Coordinates: 2618408..2618689 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q0B637
• Locus tag: BAMMC406_RS26975
• Protein ID: WP_011659781.1
• Coordinates: 2618679..2618927 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BAMMC406_RS26950	2614055..2614753	-	699	WP_012367041.1	MgtC/SapB family protein	-
BAMMC406_RS26955	2614865..2615974	+	1110	WP_012367042.1	AGE family epimerase/isomerase	-
BAMMC406_RS26960	2615947..2617581	-	1635	WP_012367043.1	Tar ligand binding domain-containing protein	-
BAMMC406_RS26965	2617842..2618285	+	444	WP_006757720.1	PaaI family thioesterase	-
BAMMC406_RS26970	2618408..2618689	-	282	WP_012367044.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BAMMC406_RS26975	2618679..2618927	-	249	WP_011659781.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
BAMMC406_RS26980	2619070..2620122	-	1053	WP_012367045.1	CoA transferase	-
BAMMC406_RS26985	2620337..2621071	+	735	WP_012367046.1	hypothetical protein	-
BAMMC406_RS26990	2621103..2622293	-	1191	WP_012367047.1	2-methylaconitate cis-trans isomerase PrpF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-81)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10983.88 Da
• Isoelectric Point: 10.7091

>T22791 WP_012367044.1 NC_010552:c2618689-2618408 [Burkholderia ambifaria MC40-6]
MTFELAFLEPALKEWKKLDRTIRDQFKSRLAERLENPRIASAKLHGHPDRYKIKLRSVGYRLVYEVRDTEVIVLVVAVGR
RDRDAVYLAAMKR

Nucleotide

• Length: 282 bp

>T22791 NC_010552:c2618689-2618408 [Burkholderia ambifaria MC40-6]
ATGACCTTTGAGCTTGCCTTTCTCGAACCTGCGTTGAAGGAGTGGAAGAAGCTCGATCGCACCATCCGCGACCAGTTCAA
ATCCCGACTCGCCGAGCGGCTCGAGAATCCCCGCATTGCGTCGGCCAAGCTGCATGGCCATCCGGATCGTTACAAGATCA
AGCTGCGCAGCGTCGGCTACCGACTCGTCTACGAAGTGCGCGATACGGAAGTGATCGTACTGGTTGTCGCAGTCGGTCGC
CGTGACCGCGATGCCGTCTATCTTGCCGCGATGAAGCGGTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8989.36 Da
• Isoelectric Point: 5.6566

>AT22791 WP_011659781.1 NC_010552:c2618927-2618679 [Burkholderia ambifaria MC40-6]
MPHTILANVTASVSELKRNPMGTVAAGEGFPVAILNHNEPAFYCIPAKTWEAMVERLEDIEDNALANTRAKDKVVKVKLN
DL

Nucleotide

• Length: 249 bp

>AT22791 NC_010552:c2618927-2618679 [Burkholderia ambifaria MC40-6]
ATGCCTCACACCATTCTGGCCAATGTTACGGCGAGCGTTTCGGAACTGAAGCGCAATCCGATGGGGACCGTCGCGGCGGG
CGAGGGCTTTCCGGTTGCGATTCTGAATCACAACGAGCCCGCGTTCTATTGCATCCCGGCGAAGACGTGGGAAGCGATGG
TCGAACGTCTCGAAGATATAGAAGACAACGCGCTTGCCAATACGCGTGCGAAGGACAAGGTCGTCAAGGTCAAGCTGAAT
GACCTTTGA

Structures

Toxin

• AlphaFold DB: B1Z1X1

Antitoxin

• AlphaFold DB: Q0B637