Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3461232..3462453 Replicon chromosome
Accession NZ_CP089238
Organism Pseudomonas aeruginosa strain JNQH-PA033

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag LSG45_RS15895 Protein ID WP_003102740.1
Coordinates 3461875..3462453 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LSG45_RS15890 Protein ID WP_031694109.1
Coordinates 3461232..3461786 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSG45_RS15865 (LSG45_15865) 3456800..3457351 + 552 WP_200199628.1 XRE family transcriptional regulator -
LSG45_RS15870 (LSG45_15870) 3457348..3457746 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
LSG45_RS15875 (LSG45_15875) 3457759..3458082 - 324 WP_003102734.1 multidrug efflux SMR transporter -
LSG45_RS15880 (LSG45_15880) 3458413..3458874 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
LSG45_RS15885 (LSG45_15885) 3458879..3461074 + 2196 WP_058172530.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
LSG45_RS15890 (LSG45_15890) 3461232..3461786 + 555 WP_031694109.1 helix-turn-helix transcriptional regulator Antitoxin
LSG45_RS15895 (LSG45_15895) 3461875..3462453 + 579 WP_003102740.1 HD domain-containing protein Toxin
LSG45_RS15900 (LSG45_15900) 3462562..3463749 - 1188 WP_003132729.1 HlyD family efflux transporter periplasmic adaptor subunit -
LSG45_RS15905 (LSG45_15905) 3463739..3465910 - 2172 WP_234574581.1 type I secretion system permease/ATPase -
LSG45_RS15910 (LSG45_15910) 3465900..3467177 - 1278 WP_003088104.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T227908 WP_003102740.1 NZ_CP089238:3461875-3462453 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

>T227908 NZ_CP123231:2752496-2752603 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20453.69 Da        Isoelectric Point: 8.9481

>AT227908 WP_031694109.1 NZ_CP089238:3461232-3461786 [Pseudomonas aeruginosa]
MTKPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT227908 NZ_CP123231:c2752443-2752382 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References