Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1610611..1612306 Replicon chromosome
Accession NZ_CP089238
Organism Pseudomonas aeruginosa strain JNQH-PA033

Toxin (Protein)


Gene name doc Uniprot ID A0A1C7C456
Locus tag LSG45_RS07520 Protein ID WP_022579703.1
Coordinates 1610611..1611480 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q9HYA1
Locus tag LSG45_RS07525 Protein ID WP_003112902.1
Coordinates 1611473..1612306 (+) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSG45_RS07495 (LSG45_07495) 1606620..1607471 + 852 WP_003130104.1 ABC transporter ATP-binding protein -
LSG45_RS07500 (LSG45_07500) 1607511..1608518 + 1008 WP_022579704.1 ABC transporter substrate-binding protein -
LSG45_RS07505 (LSG45_07505) 1608515..1609291 + 777 WP_073647081.1 ABC transporter permease -
LSG45_RS07510 (LSG45_07510) 1609297..1610058 + 762 WP_200200059.1 SDR family oxidoreductase -
LSG45_RS07515 (LSG45_07515) 1610072..1610602 + 531 WP_003112900.1 cupin domain-containing protein -
LSG45_RS07520 (LSG45_07520) 1610611..1611480 + 870 WP_022579703.1 alpha/beta hydrolase Toxin
LSG45_RS07525 (LSG45_07525) 1611473..1612306 + 834 WP_003112902.1 IclR family transcriptional regulator Antitoxin
LSG45_RS07530 (LSG45_07530) 1612293..1613090 + 798 WP_022579702.1 SDR family oxidoreductase -
LSG45_RS07535 (LSG45_07535) 1613083..1614765 + 1683 WP_031692523.1 thiamine pyrophosphate-binding protein -
LSG45_RS07540 (LSG45_07540) 1614776..1615579 + 804 WP_003112905.1 aspartate dehydrogenase -
LSG45_RS07545 (LSG45_07545) 1615591..1617075 + 1485 WP_031756606.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-272)

Antitoxin

Transcription regulator IclR, N-terminal

(16-66)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 30389.65 Da        Isoelectric Point: 6.8139

>T227906 WP_022579703.1 NZ_CP089238:1610611-1611480 [Pseudomonas aeruginosa]
MNMAQTHIPAPSLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAARLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERLGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSPIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Download         Length: 870 bp

>T227906 NZ_CP123231:2130976-2131078 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30877.26 Da        Isoelectric Point: 5.7725

>AT227906 WP_003112902.1 NZ_CP089238:1611473-1612306 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV

Download         Length: 834 bp

>AT227906 NZ_CP123231:c2131116-2130848 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C7C456

Antitoxin

Source ID Structure
AlphaFold DB Q9HYA1

References