Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 3682329..3682845 Replicon chromosome
Accession NZ_CP089236
Organism Pseudomonas aeruginosa strain JNQH-PA027

Toxin (Protein)


Gene name relE Uniprot ID A0A3R8UIH5
Locus tag LSG40_RS17385 Protein ID WP_025297453.1
Coordinates 3682329..3682610 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3R8UIM7
Locus tag LSG40_RS17390 Protein ID WP_025297454.1
Coordinates 3682600..3682845 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSG40_RS17365 (LSG40_17365) 3678072..3678719 - 648 WP_033976844.1 peptidase M15 -
LSG40_RS17370 (LSG40_17370) 3678743..3680323 - 1581 WP_070147860.1 DNA recombination protein RmuC -
LSG40_RS17375 (LSG40_17375) 3680453..3681328 + 876 WP_033976847.1 WYL domain-containing protein -
LSG40_RS17380 (LSG40_17380) 3681342..3681923 + 582 WP_033976848.1 plasmid pRiA4b ORF-3 family protein -
LSG40_RS17385 (LSG40_17385) 3682329..3682610 - 282 WP_025297453.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LSG40_RS17390 (LSG40_17390) 3682600..3682845 - 246 WP_025297454.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LSG40_RS17395 (LSG40_17395) 3683280..3683534 + 255 WP_153574174.1 hypothetical protein -
LSG40_RS17400 (LSG40_17400) 3683692..3684768 + 1077 WP_052156709.1 WYL domain-containing protein -
LSG40_RS17405 (LSG40_17405) 3684866..3687067 + 2202 WP_033976850.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3650851..3698135 47284


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(10-71)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10824.61 Da        Isoelectric Point: 10.6249

>T227899 WP_025297453.1 NZ_CP089236:c3682610-3682329 [Pseudomonas aeruginosa]
MTYELEFLPSALKEWQKLGHTVREQIKKKLRERLDNPKVQADALRDMPGHYKIKLRASGYRLVYRVEDERVVVVVVAVGK
RERGAAYQSAKGR

Download         Length: 282 bp

>T227899 NZ_CP123231:c659609-659145 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGTTCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8797.21 Da        Isoelectric Point: 4.2550

>AT227899 WP_025297454.1 NZ_CP089236:c3682845-3682600 [Pseudomonas aeruginosa]
MQSILADVAVSVSELKKNPSGILAGAGGMPVAVLNHNRVMGYMVPAELYEQMMERLDDLELVEIVKARSGEESVPVRLDD
L

Download         Length: 246 bp

>AT227899 NZ_CP123231:c659944-659609 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R8UIH5

Antitoxin

Source ID Structure
AlphaFold DB A0A3R8UIM7

References