Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 2032157..2033665 Replicon chromosome
Accession NZ_CP089236
Organism Pseudomonas aeruginosa strain JNQH-PA027

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag LSG40_RS09905 Protein ID WP_003119682.1
Coordinates 2032157..2032744 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1C7C4U7
Locus tag LSG40_RS09910 Protein ID WP_003091607.1
Coordinates 2032811..2033665 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSG40_RS09900 (LSG40_09900) 2028412..2031891 - 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
LSG40_RS09905 (LSG40_09905) 2032157..2032744 + 588 WP_003119682.1 GNAT family protein Toxin
LSG40_RS09910 (LSG40_09910) 2032811..2033665 + 855 WP_003091607.1 AraC family transcriptional regulator Antitoxin
LSG40_RS09915 (LSG40_09915) 2033762..2035927 + 2166 WP_010793245.1 TonB-dependent receptor family protein -
LSG40_RS09920 (LSG40_09920) 2036102..2037976 + 1875 WP_010793244.1 MFS transporter -
LSG40_RS09925 (LSG40_09925) 2038037..2038246 - 210 WP_003091604.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T227897 WP_003119682.1 NZ_CP089236:2032157-2032744 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

>T227897 NZ_CP123228:c1628487-1627609 [Piscinibacter sp. XHJ-5]
GTGCTCGCCCGCCTGCTGGACCTGGCGAAACAAGGCGGCCAGGACTACAGCCTCCTTCTCAACCGCTTCGGCCTCGAGCG
CCTGCTGGACCGCCTGACGAAGTCGCGGCATGCCGACCGCTTCCTGCTCAAGGGCGCCCTGCTCTTCTCGCTTTGGTACG
ACGAACCTCATCGGCCAACGCGCGATGCCGACCTGCTGGGCTTCGGCCCGGATGACGCTGAACATCTCGCGACGGTCTTT
CGCGAGATCGCAGCGATCGAGTTGGACGACGGCATCGTGTTCGACCCCGACTCCGTGCGCGTCGATCCCATCCGCGAGGA
CAACGCCTACGGCGGCAGCCGCATACGCTTGGTCGGCCACGTCGGCAACGCGCGCTGCTCCTTGCAGGTCGACGTCGGGT
TCGGAGACGCCGTCACGCCCAGCCCCGAGACCGCTCGCTATCCCGTCCTTCTCCCGGACTTCGACCGCCCAACGCTTCGC
GTCTATCCGGTCTACACCGTCATCGCCGAGAAGTACCAAGCCATGGTGACGCTCGGCGCGGCGAACAGCCGCGTGAAGGA
CTTCTACGACCTCTGCATGATCGCCAGCCGCACCTCGCTGGATGGGCAGACGTTGGCTCGCGCCATCACGGCGACCTTCA
CACGGCGCATCACGGAGATCCCTGCCGAGCCGCCGCTCGCCCTTCGGCCCGCTTTCTCCAACGACTCCGCCAAGCAACAA
CAGTGGCGCGCGTTCTTGTCCCGGAACCGCCTCGGAGAGATTGAACTGGCGGTCGCAATCGAGCTGCTCTACGCTCTGCT
GTGGCCACCGACGCAGGTCGCCGGCAGCGCGTCCGACGCCACCGCACGATGGGACGCAGCCCTACTGAAATGGGTCTAG

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31895.20 Da        Isoelectric Point: 7.5295

>AT227897 WP_003091607.1 NZ_CP089236:2032811-2033665 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp

>AT227897 NZ_CP123228:c1629116-1628511 [Piscinibacter sp. XHJ-5]
ATGACTGGCTCATCAATGGAACGCGTGATGGCTCTCGCCGCCGACCGCCGGTTGCTTCGTGGCAGCGACCTGCACGACGT
CGGCCTGTCGCCGCAGCTGCTCATCAAACTACACCAAGCGGGAAAACTGCAGCGGGTTTTTCGGGGCGTCTACAGCCTAC
CCGATGCACCGGTCACCGAGCACCAATCGCTCGCCGAAGTGTGCAGGCGAGTGCCCAAGGGGGTCGTTTGCCTTCTCTCC
GCGCTGCGCTTCCACGAGATCGGCACACAAGCGCCTCATGAAGTCTGGCTGGCACTCCCGGAGTCGAGCCGCACACCAGC
GGTCAGCTTTCCCGCCCTGCGAATCGTTCGCCTTCGCGGCGAAGCCTACTCGGAAAGCATTGAGACAGTCATGGAGGAAG
GCGCCTCGATACGCGTCTACAGCACCGCCAAGACCATCACCGACTGCTTCAAGTTCCGCCACAAGATCGGCCTCGACGTT
GCGCTGGAAGCTCTGAAAGACGCCTGGCAGCGGCGGCTCGTCAAGATGGATGACCTCAGCCGCTTCGCGCGCATCAATCG
GGTTGAGCGCGTCATGCAGCCGTACCTGGAGGCGCTCGTCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7C4U7

References