Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
| Location | 1723612..1725307 | Replicon | chromosome |
| Accession | NZ_CP089236 | ||
| Organism | Pseudomonas aeruginosa strain JNQH-PA027 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | Q9HYA0 |
| Locus tag | LSG40_RS08355 | Protein ID | WP_003112901.1 |
| Coordinates | 1723612..1724481 (+) | Length | 290 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | Q9HYA1 |
| Locus tag | LSG40_RS08360 | Protein ID | WP_003112902.1 |
| Coordinates | 1724474..1725307 (+) | Length | 278 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LSG40_RS08330 (LSG40_08330) | 1719620..1720471 | + | 852 | WP_003130104.1 | ABC transporter ATP-binding protein | - |
| LSG40_RS08335 (LSG40_08335) | 1720512..1721519 | + | 1008 | WP_003112897.1 | ABC transporter substrate-binding protein | - |
| LSG40_RS08340 (LSG40_08340) | 1721516..1722292 | + | 777 | WP_003112898.1 | ABC transporter permease | - |
| LSG40_RS08345 (LSG40_08345) | 1722298..1723059 | + | 762 | WP_003112899.1 | SDR family oxidoreductase | - |
| LSG40_RS08350 (LSG40_08350) | 1723073..1723603 | + | 531 | WP_003112900.1 | cupin domain-containing protein | - |
| LSG40_RS08355 (LSG40_08355) | 1723612..1724481 | + | 870 | WP_003112901.1 | alpha/beta hydrolase | Toxin |
| LSG40_RS08360 (LSG40_08360) | 1724474..1725307 | + | 834 | WP_003112902.1 | IclR family transcriptional regulator | Antitoxin |
| LSG40_RS08365 (LSG40_08365) | 1725294..1726091 | + | 798 | WP_003112903.1 | SDR family oxidoreductase | - |
| LSG40_RS08370 (LSG40_08370) | 1726084..1727766 | + | 1683 | WP_003130114.1 | thiamine pyrophosphate-binding protein | - |
| LSG40_RS08375 (LSG40_08375) | 1727777..1728580 | + | 804 | WP_003130116.1 | aspartate dehydrogenase | - |
| LSG40_RS08380 (LSG40_08380) | 1728592..1730076 | + | 1485 | WP_003453562.1 | aldehyde dehydrogenase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 290 a.a. Molecular weight: 30403.60 Da Isoelectric Point: 6.5894
>T227896 WP_003112901.1 NZ_CP089236:1723612-1724481 [Pseudomonas aeruginosa]
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG
Download Length: 870 bp
>T227896 NZ_CP123227:100417-100767 [Pseudomonas amygdali pv. aesculi]
ATGAACACGTTTGCACTACGCTTTACCGAGGTTGCCCAGCAAAGCATTGAAGATCAGGTCGAGCACCTGGCTATCACTCA
GGGATTCTCATTAGCTGCTCAACGTATAAATACCCTGATCGATGTCATCCAGGACAAGCTCTTGTCCACCCCGTTGGGCT
ACCCGGTCAGTCCTCAATTGAGTGAGCTGGGTATACTGCACTATCGTGAGTTGAACACTGACGGATACCGGATCTTTTAC
GAGGTCATGGATTCTGATGGTATTACCGACATCGCCGTATTGCTCGTATTAGGCGGGAAACAAAGTGTGGAGCAGGCTCT
GATCCGCTACTGCCTGCTCCAGCCGATGTAG
ATGAACACGTTTGCACTACGCTTTACCGAGGTTGCCCAGCAAAGCATTGAAGATCAGGTCGAGCACCTGGCTATCACTCA
GGGATTCTCATTAGCTGCTCAACGTATAAATACCCTGATCGATGTCATCCAGGACAAGCTCTTGTCCACCCCGTTGGGCT
ACCCGGTCAGTCCTCAATTGAGTGAGCTGGGTATACTGCACTATCGTGAGTTGAACACTGACGGATACCGGATCTTTTAC
GAGGTCATGGATTCTGATGGTATTACCGACATCGCCGTATTGCTCGTATTAGGCGGGAAACAAAGTGTGGAGCAGGCTCT
GATCCGCTACTGCCTGCTCCAGCCGATGTAG
Antitoxin
Download Length: 278 a.a. Molecular weight: 30877.26 Da Isoelectric Point: 5.7725
>AT227896 WP_003112902.1 NZ_CP089236:1724474-1725307 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV
Download Length: 834 bp
>AT227896 NZ_CP123227:100156-100404 [Pseudomonas amygdali pv. aesculi]
ATGCGAGTTGAAACAATAAGTTATCTGAAACGTAACGCAGCCGACCTGCCTCTCGATGAGCCACTGGTTGTCACGCAAAA
CGGTGTCCCGGCCTACGTGGTGGAGTCTTACGCAGATCGTAAGCGCCGCGATGAGTCGATCGCCTTGGTAAAGCTCCTGG
CGATCAGTTCCCGCGATTACTCCCAAGGCAAGCACTGTTCCACTGACGAACTTAAAGCCCGGTTGAGCAGGAGGTTTGCC
CAAAAATAA
ATGCGAGTTGAAACAATAAGTTATCTGAAACGTAACGCAGCCGACCTGCCTCTCGATGAGCCACTGGTTGTCACGCAAAA
CGGTGTCCCGGCCTACGTGGTGGAGTCTTACGCAGATCGTAAGCGCCGCGATGAGTCGATCGCCTTGGTAAAGCTCCTGG
CGATCAGTTCCCGCGATTACTCCCAAGGCAAGCACTGTTCCACTGACGAACTTAAAGCCCGGTTGAGCAGGAGGTTTGCC
CAAAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|