Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4871734..4872250 Replicon chromosome
Accession NZ_CP089234
Organism Klebsiella sp. KPN54798

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag LPQ25_RS23360 Protein ID WP_004178374.1
Coordinates 4871734..4872018 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LPQ25_RS23365 Protein ID WP_002886901.1
Coordinates 4872008..4872250 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPQ25_RS23335 (4867130) 4867130..4867393 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
LPQ25_RS23340 (4867523) 4867523..4867696 + 174 WP_041169004.1 hypothetical protein -
LPQ25_RS23345 (4867699) 4867699..4868442 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LPQ25_RS23350 (4868799) 4868799..4870937 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LPQ25_RS23355 (4871266) 4871266..4871730 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LPQ25_RS23360 (4871734) 4871734..4872018 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LPQ25_RS23365 (4872008) 4872008..4872250 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LPQ25_RS23370 (4872328) 4872328..4874238 - 1911 WP_012737231.1 PRD domain-containing protein -
LPQ25_RS23375 (4874261) 4874261..4875415 - 1155 WP_012737230.1 lactonase family protein -
LPQ25_RS23380 (4875482) 4875482..4876222 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T227890 WP_004178374.1 NZ_CP089234:c4872018-4871734 [Klebsiella sp. KPN54798]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T227890 NZ_CP123222:70058-70324 [Pseudomonas amygdali pv. aesculi]
TTGGCCTGGACGATTGATTACACCGACACGGCCAAAACACAGTTGCGGAAGCTCGACAAGCAGTCAGCGAAGCGCATTCT
TGACTTTATGGATGAACGGGTGTCCAGCAGGGACGATCCGAGAACTACTGGCAAGGCGCTAACAGGCCCATTGGGGGGCT
TGTGGCGGTATCGCGTAGGAGACTTCCGGGTAATCTGCGAGATACAGGACGGCGCCTTACGGATACTGGTTGTACAGCTT
GGCAACCGTCGAGAAGTTTACCGCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT227890 WP_002886901.1 NZ_CP089234:c4872250-4872008 [Klebsiella sp. KPN54798]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT227890 NZ_CP123222:69847-70074 [Pseudomonas amygdali pv. aesculi]
ATGGCCACTTCCATTCGCTTGGCACCCGAAACCGAGCAGCGCCTAGATTTTTTGGCGACAAGCACCGGGCGTACCAAGGC
GTATTATCTGCGCGAAATCATCGATCATGGCCTGACTGACCTTGAGGATTACTACCTCGCGGCTGAAGTCCTGGAGCGAG
TCCGTAAAAATACAGAGGTCGTTCACTCTGCTGCGGACGTAAGGAAAGACCTTGGCCTGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References