Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4111047..4111666 Replicon chromosome
Accession NZ_CP089234
Organism Klebsiella sp. KPN54798

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LPQ25_RS19770 Protein ID WP_002892050.1
Coordinates 4111448..4111666 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LPQ25_RS19765 Protein ID WP_002892066.1
Coordinates 4111047..4111421 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPQ25_RS19755 (4106199) 4106199..4107392 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LPQ25_RS19760 (4107415) 4107415..4110561 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
LPQ25_RS19765 (4111047) 4111047..4111421 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LPQ25_RS19770 (4111448) 4111448..4111666 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LPQ25_RS19775 (4111825) 4111825..4112391 + 567 WP_002892030.1 maltose O-acetyltransferase -
LPQ25_RS19780 (4112363) 4112363..4112503 - 141 WP_004147370.1 hypothetical protein -
LPQ25_RS19785 (4112524) 4112524..4112994 + 471 WP_002892026.1 YlaC family protein -
LPQ25_RS19790 (4112969) 4112969..4114420 - 1452 WP_014907971.1 PLP-dependent aminotransferase family protein -
LPQ25_RS19795 (4114521) 4114521..4115219 + 699 WP_002892021.1 GNAT family protein -
LPQ25_RS19800 (4115216) 4115216..4115356 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LPQ25_RS19805 (4115356) 4115356..4115619 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T227889 WP_002892050.1 NZ_CP089234:4111448-4111666 [Klebsiella sp. KPN54798]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T227889 NZ_CP123222:30070-30396 [Pseudomonas amygdali pv. aesculi]
ATGATGCGAGGTGACCTAGTCACCGTCGCCATGCAAGGTGACTTTGGTAAACCAAGACCCGCCTTGGTAATTCAGGCAAA
CCAATTCAGCGAACACACCAGCGTTACCGTGCTGCCAGTGACCAGCACCCTAGTCGCAGCACCGCTGCTGCGCATCACCG
TTCAGCCGACCGCAGAAAACGGCTTGCAGAAGCCTTCTCAGGTCATGCTAGACAAGACCATGACACTCAAGCGTGAAAAA
ATAGGTCCGACTTTTGGGCATATCGGAGTGGATTCAATGGTGGAGGTGGAGCGCTGTTTAGCCGTGTTCTTGGGTATCGC
CAATTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT227889 WP_002892066.1 NZ_CP089234:4111047-4111421 [Klebsiella sp. KPN54798]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT227889 NZ_CP123222:29849-30073 [Pseudomonas amygdali pv. aesculi]
ATGCCTACATCCCATGTAAATGCCCGCGTTCAACGCCATCGCGACGCGCTGCGTGCGGCTGGCCTACGGCCCATTCAGAT
TTGGGTTCCCGATACCCGGCGGCCAGACTTTGCACAGGAGTGCCATCGACAGTGCCTGTTGGTTGCTCAGGCAGACATGG
CCAATACCTATATGCAGGGGTTGATGGACGAAGCCTTAGACGATGTTGAGGGTTGGACGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References