Detailed information of TA system TA022788

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1830227..1830882
• Replicon: chromosome
• Accession: NC_010552
• Organism: Burkholderia ambifaria MC40-6

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: B1YY30
• Locus tag: BAMMC406_RS23665
• Protein ID: WP_012366457.1
• Coordinates: 1830227..1830646 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: BAMMC406_RS23670
• Protein ID: WP_041490076.1
• Coordinates: 1830643..1830882 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BAMMC406_RS23640	1825593..1826387	+	795	WP_012366453.1	AraC family transcriptional regulator	-
BAMMC406_RS23645	1826669..1827628	+	960	WP_012366454.1	DMT family transporter	-
BAMMC406_RS23650	1827754..1828326	+	573	WP_012366455.1	hypothetical protein	-
BAMMC406_RS23655	1828426..1828560	-	135	WP_011659177.1	entericidin A/B family lipoprotein	-
BAMMC406_RS23660	1828795..1830090	+	1296	WP_012366456.1	aspartate carbamoyltransferase	-
BAMMC406_RS23665	1830227..1830646	-	420	WP_012366457.1	type II toxin-antitoxin system VapC family toxin	Toxin
BAMMC406_RS23670	1830643..1830882	-	240	WP_041490076.1	Arc family DNA-binding protein	Antitoxin
BAMMC406_RS23675	1831204..1833447	+	2244	WP_012366459.1	TonB-dependent siderophore receptor	-
BAMMC406_RS23680	1833451..1834206	+	756	WP_012366460.1	sel1 repeat family protein	-
BAMMC406_RS23685	1834203..1834886	+	684	WP_012366461.1	Fe2+-dependent dioxygenase	-
BAMMC406_RS34645	1835119..1835592	+	474	WP_012366462.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-122)

Antitoxin

• Arc-like DNA binding domain (7-44)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15003.27 Da
• Isoelectric Point: 5.8793

>T22788 WP_012366457.1 NC_010552:c1830646-1830227 [Burkholderia ambifaria MC40-6]
MILVDTNVISEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFGVAALPEGRRRDWLHQSIEQRVVPLFRGRILPFDD
AASKAYASLCAKARATGNAMASADGFIAATAAANGLIVATRDVAPFEAAGLRVIDPWAR

Nucleotide

• Length: 420 bp

>T22788 NC_010552:c1830646-1830227 [Burkholderia ambifaria MC40-6]
ATGATCCTCGTCGATACCAACGTCATTTCCGAGCCGCTGCGGCGCGAGCCGAGTGCGGCCGTGATCGAATGGCTCGATGC
GCAGAATGTCGAGACGCTGTTTCTTGCCGCGATCAGTCTCGCGGAAATGCGTTTCGGCGTGGCTGCGTTGCCGGAAGGGA
GAAGGCGGGACTGGCTGCACCAAAGCATCGAGCAGCGCGTCGTGCCGCTGTTTCGCGGTCGGATCCTGCCGTTCGACGAT
GCGGCCAGTAAAGCCTATGCGAGCCTTTGTGCGAAGGCTCGTGCCACCGGCAACGCGATGGCGTCTGCCGATGGATTTAT
CGCTGCAACGGCCGCGGCGAACGGGTTGATCGTGGCGACGCGTGACGTCGCGCCGTTCGAAGCGGCGGGCTTGCGCGTGA
TCGACCCGTGGGCCCGGTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8667.87 Da
• Isoelectric Point: 6.2210

>AT22788 WP_041490076.1 NC_010552:c1830882-1830643 [Burkholderia ambifaria MC40-6]
MPVITVRNLPDEVHRALRIRAAQHGRSTEAEVRAILEEAVRPTGRAKLGTLLAEIGREAGGIDFEIPHVNSPTDPMSFE

Nucleotide

• Length: 240 bp

>AT22788 NC_010552:c1830882-1830643 [Burkholderia ambifaria MC40-6]
ATGCCGGTTATTACCGTTCGAAATTTGCCCGACGAGGTGCATCGCGCGCTTCGCATCCGTGCGGCGCAACATGGTCGGAG
CACCGAAGCGGAGGTGCGCGCCATCCTCGAGGAAGCCGTTCGGCCCACCGGCCGGGCGAAGCTGGGGACGCTGCTGGCTG
AAATCGGGCGCGAGGCGGGCGGTATCGATTTCGAGATTCCGCATGTGAACTCGCCAACCGATCCGATGAGCTTCGAATGA

Structures

Toxin

• AlphaFold DB: B1YY30