Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 731759..732534 Replicon chromosome
Accession NZ_CP089234
Organism Klebsiella sp. KPN54798

Toxin (Protein)


Gene name TacT2 Uniprot ID B6ZBI6
Locus tag LPQ25_RS03625 Protein ID WP_004889762.1
Coordinates 732049..732534 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag LPQ25_RS03620 Protein ID WP_004150912.1
Coordinates 731759..732052 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPQ25_RS03600 (726968) 726968..727570 - 603 WP_002916735.1 short chain dehydrogenase -
LPQ25_RS03605 (727668) 727668..728579 + 912 WP_014906929.1 LysR family transcriptional regulator -
LPQ25_RS03610 (728580) 728580..729728 - 1149 WP_014906930.1 PLP-dependent aspartate aminotransferase family protein -
LPQ25_RS03615 (729739) 729739..731115 - 1377 WP_014906931.1 pyridoxal-phosphate dependent enzyme -
LPQ25_RS03620 (731759) 731759..732052 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
LPQ25_RS03625 (732049) 732049..732534 + 486 WP_004889762.1 GNAT family N-acetyltransferase Toxin
LPQ25_RS03630 (733238) 733238..733831 + 594 WP_004188553.1 hypothetical protein -
LPQ25_RS03635 (733928) 733928..734144 + 217 Protein_714 transposase -
LPQ25_RS03645 (734820) 734820..735533 - 714 WP_002916694.1 DUF554 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 733928..734080 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17585.56 Da        Isoelectric Point: 8.5144

>T227878 WP_004889762.1 NZ_CP089234:732049-732534 [Klebsiella sp. KPN54798]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDSMMLMVTLRDLVN
A

Download         Length: 486 bp

>T227878 NZ_CP123214:99128-99478 [Pseudomonas amygdali pv. aesculi]
ATGAACACGTTTGCACTACGCTTTACCGAGGTTGCCCAGCAAAGCATTGAAGATCAGGTCGAGCACCTGGCTATCACTCA
GGGATTCTCATTAGCTGCTCAACGTATAAATACCCTGATCGATGTCATCCAGGACAAGCTCTTGTCCACCCCGTTGGGCT
ACCCGGTCAGTCCTCAATTGAGTGAGCTGGGTATACTGCACTATCGTGAGTTGAACACTGACGGATACCGGATCTTTTAC
GAGGTCATGGATTCTGATGGTATTACCGACATCGCCGTATTGCTCGTATTAGGCGGGAAACAAAGTGTGGAGCAGGCTCT
GATCCGCTACTGCCTGCTCCAGCCGATGTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT227878 WP_004150912.1 NZ_CP089234:731759-732052 [Klebsiella sp. KPN54798]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT227878 NZ_CP123214:98867-99115 [Pseudomonas amygdali pv. aesculi]
ATGCGAGTTGAAACAATAAGTTATCTGAAACGTAACGCAGCCGACCTGCCTCTCGATGAGCCACTGGTTGTCACGCAAAA
CGGTGTCCCGGCCTACGTGGTGGAGTCTTACGCAGATCGTAAGCGCCGCGATGAGTCGATCGCCTTGGTAAAGCTCCTGG
CGATCAGTTCCCGCGATTACTCCCAAGGCAAGCACTGTTCCACTGACGAACTTAAAGCCCGGTTGAGCAGGAGGTTTGCC
CAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A447W563

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References