Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Fic(toxin)
Location 3505730..3506295 Replicon chromosome
Accession NZ_CP089225
Organism Nocardia gipuzkoensis strain FDAARGOS_1619

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag LTT66_RS15760 Protein ID WP_233069279.1
Coordinates 3505924..3506295 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag LTT66_RS15755 Protein ID WP_233068221.1
Coordinates 3505730..3505927 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LTT66_RS15730 (LTT66_15730) 3500817..3501236 + 420 WP_233068210.1 glyoxalase/bleomycin resistance/extradiol dioxygenase family protein -
LTT66_RS15735 (LTT66_15735) 3501301..3502083 - 783 WP_233068213.1 crotonase/enoyl-CoA hydratase family protein -
LTT66_RS15740 (LTT66_15740) 3502145..3503794 + 1650 WP_233068215.1 acyl-CoA synthetase -
LTT66_RS15745 (LTT66_15745) 3503810..3504997 - 1188 WP_233068217.1 FAD-dependent monooxygenase -
LTT66_RS15750 (LTT66_15750) 3505099..3505686 + 588 WP_233068219.1 TetR family transcriptional regulator -
LTT66_RS15755 (LTT66_15755) 3505730..3505927 + 198 WP_233068221.1 antitoxin Phd Antitoxin
LTT66_RS15760 (LTT66_15760) 3505924..3506295 + 372 WP_233069279.1 Fic family protein Toxin
LTT66_RS15765 (LTT66_15765) 3506362..3507480 - 1119 WP_233068223.1 acyl-CoA dehydrogenase family protein -
LTT66_RS15770 (LTT66_15770) 3507500..3508693 - 1194 WP_233068232.1 acyl-CoA dehydrogenase family protein -
LTT66_RS15775 (LTT66_15775) 3508902..3509090 + 189 WP_043686375.1 ferredoxin -
LTT66_RS15780 (LTT66_15780) 3509134..3510036 + 903 WP_233068234.1 3-oxoacyl-ACP reductase -
LTT66_RS15785 (LTT66_15785) 3510327..3511091 + 765 WP_181718959.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(22-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13849.75 Da        Isoelectric Point: 4.5377

>T227872 WP_233069279.1 NZ_CP089225:3505924-3506295 [Nocardia gipuzkoensis]
MMEYLTLPELLNLAERLGTPTVRDYGLLDSALARPRSSVFGQDAYPDVWQKAAALMESIARNHGLVDGNKRLAWYASWVF
LQMNGHRLDPRFDVDDAEQFVLDVCQGVLDVPAIAEHLAKFES

Download         Length: 372 bp

>T227872 NZ_CP123211:24297-24563 [Pseudomonas amygdali pv. aesculi]
TTGGCCTGGACGATTGATTACACCGACACGGCCAAAACACAGTTGCGGAAGCTCGACAAGCAGTCAGCGAAGCGCATTCT
TGACTTTATGGATGAACGGGTGTCCAGCAGGGACGATCCGAGAACTACTGGCAAGGCGCTAACAGGCCCATTGGGGGGCT
TGTGGCGGTATCGCGTAGGAGACTTCCGGGTAATCTGCGAGATACAGGACGGCGCCTTACGGATACTGGTTGTACAGCTT
GGCAACCGTCGAGAAGTTTACCGCTGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7417.33 Da        Isoelectric Point: 6.2170

>AT227872 WP_233068221.1 NZ_CP089225:3505730-3505927 [Nocardia gipuzkoensis]
MAGLNIRFSDQELGALRERAEAEGRSMQQFVHDAVIKAINEHSRLFNEAADHVLRVSEELNRRLA

Download         Length: 198 bp

>AT227872 NZ_CP123211:24086-24313 [Pseudomonas amygdali pv. aesculi]
ATGGCCACTTCCATTCGCTTGGCACCCGAAACCGAGCAGCGCCTAGATTTTTTGGCGACAAGCACCGGGCGTACCAAGGC
GTATTATCTGCGCGAAATCATCGATCATGGCCTGACTGACCTTGAGGATTACTACCTCGCGGCTGAAGTCCTGGAGCGAG
TCCGTAAAAATACAGAGGTCGTTCACTCTGCTGCGGACGTAAGGAAAGACCTTGGCCTGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References