Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1671685..1673450 Replicon chromosome
Accession NC_010552
Organism Burkholderia ambifaria MC40-6

Toxin (Protein)


Gene name doc Uniprot ID B1YXF9
Locus tag BAMMC406_RS22930 Protein ID WP_012366321.1
Coordinates 1672539..1673450 (-) Length 304 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID B1YXF8
Locus tag BAMMC406_RS22925 Protein ID WP_012366320.1
Coordinates 1671685..1672542 (-) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BAMMC406_RS22905 1666823..1668313 - 1491 WP_012366316.1 aldehyde dehydrogenase -
BAMMC406_RS22910 1668411..1669238 - 828 WP_012366317.1 aspartate dehydrogenase -
BAMMC406_RS22915 1669231..1670898 - 1668 WP_012366318.1 thiamine pyrophosphate-binding protein -
BAMMC406_RS22920 1670891..1671688 - 798 WP_012366319.1 SDR family oxidoreductase -
BAMMC406_RS22925 1671685..1672542 - 858 WP_012366320.1 IclR family transcriptional regulator Antitoxin
BAMMC406_RS22930 1672539..1673450 - 912 WP_012366321.1 alpha/beta fold hydrolase Toxin
BAMMC406_RS22935 1673470..1673997 - 528 WP_012366322.1 cupin domain-containing protein -
BAMMC406_RS22940 1674037..1674807 - 771 WP_012366323.1 SDR family oxidoreductase -
BAMMC406_RS22945 1674800..1675870 - 1071 WP_012366324.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
BAMMC406_RS22950 1675925..1676236 - 312 WP_012366325.1 hypothetical protein -
BAMMC406_RS22955 1676238..1676555 - 318 WP_006751284.1 non-heme iron oxygenase ferredoxin subunit -
BAMMC406_RS22960 1677006..1678085 + 1080 WP_012366326.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(56-284)

Antitoxin

Transcription regulator IclR, N-terminal

(24-72)


Sequences

Toxin        


Download         Length: 304 a.a.        Molecular weight: 31232.51 Da        Isoelectric Point: 6.8171

>T22787 WP_012366321.1 NC_010552:c1673450-1672539 [Burkholderia ambifaria MC40-6]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAGEAGAQHAGHALPVVLLHGIGSGAASWVCQLDTLGASR
RVLAWDAPGYGVSTPVHGASPSAADYAASLNAWLEALGIERCVLVGHSLGAIIAGGLCRLMPARIAGLLLISPAGGYGRA
PVETRDTRRDARLAMLDELGPAGLAEQRSGNMLSGFASEDARAWVRWNMARIVPAGYAQATHLLANADLATDLAGFRGRA
AVAVGANDAITPPAACERIAAAAQVELQVIPQAGHAGYVEAPAVYSSLIDTFCRQCDTQRGMA

Download         Length: 912 bp

>T22787 NC_010552:c1673450-1672539 [Burkholderia ambifaria MC40-6]
ATGAGTGTCATCGACAAACGTGAACGCGACCGCACCGCGGCATTCGCCGCGCTGCTCGGGCAGTTTCCCGAACAGCGCTG
CGCGGCCGGCGCGGCGGGCACGATCGGTTACCGTGAGGCTGGCGCAGGCGAGGCCGGCGCGCAGCATGCGGGCCACGCGC
TGCCCGTCGTGCTGCTGCACGGGATCGGCTCGGGCGCCGCATCGTGGGTGTGCCAGCTCGACACGCTCGGCGCGTCGCGA
CGCGTGCTCGCGTGGGATGCGCCCGGCTACGGCGTGTCGACCCCCGTGCACGGCGCGTCGCCGAGCGCCGCCGATTACGC
GGCGTCGCTGAACGCGTGGCTCGAGGCACTCGGCATCGAACGCTGCGTGCTGGTCGGGCATTCGCTCGGCGCGATCATCG
CGGGTGGCTTGTGCCGCCTGATGCCCGCGCGGATCGCCGGCCTGCTGCTGATCTCGCCCGCGGGCGGCTACGGCCGCGCG
CCCGTCGAAACGCGCGACACGCGCCGCGACGCGCGCCTCGCGATGCTTGACGAACTCGGTCCGGCCGGGCTCGCCGAGCA
GCGCAGCGGCAACATGCTGTCGGGTTTCGCGAGCGAGGATGCGCGTGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGC
CGGCCGGCTATGCGCAGGCCACGCATCTGCTCGCGAACGCCGATCTCGCGACCGATCTCGCCGGCTTTCGCGGCCGCGCG
GCCGTGGCCGTCGGCGCGAACGACGCGATCACGCCGCCCGCCGCGTGCGAGCGGATCGCCGCGGCCGCGCAGGTCGAGCT
GCAGGTAATTCCGCAGGCTGGCCATGCCGGCTACGTGGAAGCGCCGGCCGTCTATTCATCGCTGATCGACACGTTCTGTC
GTCAGTGCGACACGCAGCGAGGCATGGCATGA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31349.83 Da        Isoelectric Point: 6.3579

>AT22787 WP_012366320.1 NC_010552:c1672542-1671685 [Burkholderia ambifaria MC40-6]
MSEPLQQAESESTKADAGYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQCQSPVFSAIRVNVGTRLPAHATTHGH
VLMGDLSLKELRALYSEGTLSRMTSATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNDTQKIVACITVTVP
RPEIDEALIADGLFDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 858 bp

>AT22787 NC_010552:c1672542-1671685 [Burkholderia ambifaria MC40-6]
ATGAGCGAACCGCTGCAACAAGCAGAATCCGAGAGCACCAAGGCCGACGCCGGCTATGTTGTGCCGGGCCTCGAACGCGG
CCTGCGGATCCTCGCCGAATTCTCGCCGCGCGAGCCGGTGCTCGGCGCGCCGGAGCTGTCCAAGCGCCTCGGCATTCCGC
GCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTTCTCGAGCGTGCGGACAAGGATCGCAACTACAAG
CTCGGCATCGCCGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGCTGGAGTTGACCGATCTCGGCCTGCCGGTGATCGA
GAGCCTGCGCGACGCGACCGGCTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGC
AGTGCCAGTCGCCGGTGTTCAGCGCGATTCGCGTGAACGTCGGCACGCGGCTGCCCGCGCATGCGACGACCCACGGCCAC
GTGCTGATGGGCGACCTGTCGCTGAAGGAGCTGCGTGCGCTGTACTCGGAAGGCACGTTGAGCCGGATGACGAGCGCGAC
GCCGGAAACGGTCGACGCGCTGTACGAAGTGATCCGCGAGGATGCGCTGCGCGGCTACGGCGTGAGCAATTCGTCGTTCG
AGCGCGGTATCTCGGTGGTCACGGCGCCGGTGCGCAACGACACGCAGAAGATCGTCGCATGCATCACGGTGACGGTGCCG
CGGCCGGAGATCGACGAGGCGCTGATCGCCGACGGCCTGTTCGACAAGGTGCAGCGCGCGGCGGCGGAACTGTCGCGGCG
GCTCAATTACCGCTCGGATGACGAGCACACGTTTCTGAAGGCTTTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B1YXF9

Antitoxin

Source ID Structure
AlphaFold DB B1YXF8

References