227865

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 4869603..4870294 Replicon chromosome
Accession NZ_CP089224
Organism Mycobacterium ostraviense strain FDAARGOS_1613

Toxin (Protein)


Gene name vapC Uniprot ID A0A164DX26
Locus tag LTS72_RS22255 Protein ID WP_075509541.1
Coordinates 4869860..4870294 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A164DX44
Locus tag LTS72_RS22250 Protein ID WP_075509542.1
Coordinates 4869603..4869863 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LTS72_RS22235 (LTS72_22235) 4865813..4866508 + 696 WP_082276984.1 phosphatidylserine decarboxylase -
LTS72_RS22240 (LTS72_22240) 4866505..4867365 + 861 WP_075509544.1 CDP-diacylglycerol--serine O-phosphatidyltransferase -
LTS72_RS22245 (LTS72_22245) 4867362..4869557 + 2196 WP_075509543.1 AAA family ATPase -
LTS72_RS22250 (LTS72_22250) 4869603..4869863 + 261 WP_075509542.1 ribbon-helix-helix protein, CopG family Antitoxin
LTS72_RS22255 (LTS72_22255) 4869860..4870294 + 435 WP_075509541.1 type II toxin-antitoxin system VapC family toxin Toxin
LTS72_RS22260 (LTS72_22260) 4870303..4870950 - 648 WP_075509540.1 LON peptidase substrate-binding domain-containing protein -
LTS72_RS22265 (LTS72_22265) 4870997..4872160 - 1164 WP_082276988.1 glutamate--cysteine ligase -
LTS72_RS22270 (LTS72_22270) 4872141..4872857 - 717 WP_075509538.1 superoxide dismutase family protein -
LTS72_RS22275 (LTS72_22275) 4872983..4873456 - 474 WP_075509537.1 LytR C-terminal domain-containing protein -
LTS72_RS22280 (LTS72_22280) 4873521..4873829 - 309 WP_023370272.1 DUF3263 domain-containing protein -
LTS72_RS22285 (LTS72_22285) 4874097..4874690 + 594 WP_075509536.1 peptide deformylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-134)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-40)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 16015.08 Da        Isoelectric Point: 4.6623

>T227865 WP_075509541.1 NZ_CP089224:4869860-4870294 [Mycobacterium ostraviense]
VIIPDVNLLLYAVITGFPQHRRAYAWWYDTVNGPERVGLTYPAIFGFLRIATNARILTEPLSATEAVSYARDWLTQPNVD
LLTASGRHLDLALGLLEELGTASNLTTDVQLAAYAIEHNAEMHSSDADFARFAGLTWTDPLRDR

Download         Length: 435 bp

>T227865 NZ_CP123205:92908-93180 [Pseudomonas amygdali pv. aesculi]
GTGCTAGTTGAGTGGCTTCCACAAGCTTTGGAGGCACTGGAGGAAATCGCCGGCTACCTAGCCGAGCGCAACCCTTATGC
TGCCGAGCAAATGCAGGCCACCCTTGAGGCCACGGTCGAGGCTCTCCCCCTGCACCCTTACATCCACCGTCCCGGCCGTG
TTCCAGGAACGCGCGAAGCGGTTGTGCATCCCAACTACCTGGTTGTCTACCGCGTCGGTACAGAGCGCATCAGCATCGTG
GACGTCCTGCACGCCCGCCAAGAGTACCCCTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10029.52 Da        Isoelectric Point: 8.7459

>AT227865 WP_075509542.1 NZ_CP089224:4869603-4869863 [Mycobacterium ostraviense]
MRTTLTLDEDVVRLIEEAVHRERRPMKHVINDALRKALAQPMEPRTPYELKPHRSAVRPGFDLAGFNRLADEMEDQAILD
RTRPAR

Download         Length: 261 bp

>AT227865 NZ_CP123205:92733-92918 [Pseudomonas amygdali pv. aesculi]
ATGAGCATTCAACTTGACCCTCGCGTCTCGGAGTTCGAGACCCAGGAACAGGCCGACAATTACGACCGTTGGTTTCGCCA
GCGTATCGAGCACAGTTTGGCCGATCCGCGTCCACCCGTGCCGCACGATGAAGCAATGGCTCGCGTCAGAGCCATGATCG
AGGCAAAGCGCCGCCGTGCTAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A164DX26

Antitoxin

Source ID Structure
AlphaFold DB A0A164DX44

References