227864

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 4634460..4635085 Replicon chromosome
Accession NZ_CP089224
Organism Mycobacterium ostraviense strain FDAARGOS_1613

Toxin (Protein)


Gene name vapC Uniprot ID A0A163VM86
Locus tag LTS72_RS21100 Protein ID WP_075513127.1
Coordinates 4634460..4634861 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A163VM96
Locus tag LTS72_RS21105 Protein ID WP_075513128.1
Coordinates 4634858..4635085 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LTS72_RS21090 (LTS72_21090) 4632111..4633239 - 1129 Protein_4187 MFS transporter -
LTS72_RS21095 (LTS72_21095) 4633419..4634375 - 957 WP_075513126.1 class I SAM-dependent methyltransferase -
LTS72_RS21100 (LTS72_21100) 4634460..4634861 - 402 WP_075513127.1 PIN domain-containing protein Toxin
LTS72_RS21105 (LTS72_21105) 4634858..4635085 - 228 WP_075513128.1 antitoxin Antitoxin
LTS72_RS21110 (LTS72_21110) 4635207..4637762 + 2556 WP_075513129.1 SEC-C domain-containing protein -
LTS72_RS21115 (LTS72_21115) 4637845..4638996 + 1152 WP_075513130.1 FIST N-terminal domain-containing protein -
LTS72_RS21120 (LTS72_21120) 4639112..4639475 - 364 Protein_4193 type II toxin-antitoxin system VapC family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13961.80 Da        Isoelectric Point: 6.1173

>T227864 WP_075513127.1 NZ_CP089224:c4634861-4634460 [Mycobacterium ostraviense]
VIALLDANVLIALVVAEHVHHDAAAAWLSTRDAGFATCPITQGSLVRFLLRTGQSAAAAREVVSAVETATRHEFWPDSVS
FADVEIGGVVGHRQVTDAYLAQLARSRNGQLATLDSGLAHLHSDVAALIPTAC

Download         Length: 402 bp

>T227864 NZ_CP123205:11762-12034 [Pseudomonas amygdali pv. aesculi]
GTGCTAGTTGAGTGGCTTCCACAAGCTTTGGAGGCACTGGAGGAAATCGCCGGCTACCTAGCCGAGCGCAACCCTTATGC
TGCCGAGCAAATGCAGGCCACCCTTGAGGCCACGGTCGAGGCTCTCCCCCTGCACCCTTACATCCACCGTCCCGGCCGTG
TTCCAGGAACGCGCGAAGCGGTTGTGCATCCCAACTACCTGGTTGTCTACCGCGTCGGTACAGAGCGCATCAGCATCGTG
GACGTCCTGCACGCCCGCCAAGAGTACCCCTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8098.18 Da        Isoelectric Point: 5.7974

>AT227864 WP_075513128.1 NZ_CP089224:c4635085-4634858 [Mycobacterium ostraviense]
VRTTIDLPDDLHKQALAIARDTRRTLSETVADLMRRGLVAGRTAAISTDPRTGLPLVSVGKVVTSEDVRSLEDEA

Download         Length: 228 bp

>AT227864 NZ_CP123205:11587-11772 [Pseudomonas amygdali pv. aesculi]
ATGAGCATTCAACTTGACCCTCGCGTCTCGGAGTTCGAGACCCAGGAACAGGCCGACAATTACGACCGTTGGTTTCGCCT
GCGTATCGAGCGCAGTTTGGCCGATCCGCGTCCACCCGTGCCGCACGATGAAGCAATGGCTCGCGTCAGAGCCATGATTG
AGGCAAAGCGCCGCCGTGCTAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A163VM86

Antitoxin

Source ID Structure
AlphaFold DB A0A163VM96

References