227863

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 4618362..4618969 Replicon chromosome
Accession NZ_CP089224
Organism Mycobacterium ostraviense strain FDAARGOS_1613

Toxin (Protein)


Gene name mazF Uniprot ID A0A163T172
Locus tag LTS72_RS21035 Protein ID WP_075513613.1
Coordinates 4618362..4618703 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A163T159
Locus tag LTS72_RS21040 Protein ID WP_075513612.1
Coordinates 4618700..4618969 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LTS72_RS21015 (LTS72_21015) 4613807..4614241 - 435 Protein_4172 sulfotransferase -
LTS72_RS21020 (LTS72_21020) 4614238..4614669 - 432 Protein_4173 cytochrome P450 -
LTS72_RS21025 (LTS72_21025) 4614783..4616060 - 1278 WP_233026825.1 group II intron reverse transcriptase/maturase -
LTS72_RS21030 (LTS72_21030) 4616706..4617878 - 1173 WP_233026826.1 IS110 family transposase -
LTS72_RS21035 (LTS72_21035) 4618362..4618703 - 342 WP_075513613.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LTS72_RS21040 (LTS72_21040) 4618700..4618969 - 270 WP_075513612.1 antitoxin Antitoxin
LTS72_RS21045 (LTS72_21045) 4619239..4619619 + 381 WP_075513611.1 hypothetical protein -
LTS72_RS21050 (LTS72_21050) 4619616..4621973 + 2358 WP_075513610.1 helicase C-terminal domain-containing protein -
LTS72_RS21055 (LTS72_21055) 4622129..4622641 + 513 WP_142361264.1 hypothetical protein -
LTS72_RS21060 (LTS72_21060) 4622638..4623576 + 939 WP_142361265.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-101)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12308.92 Da        Isoelectric Point: 7.9630

>T227863 WP_075513613.1 NZ_CP089224:c4618703-4618362 [Mycobacterium ostraviense]
VTPLRGQVYRCDVGYGPKPWLIVSNNPRNRRTADVVAIRLTTTARRLPTWVPLSSDDPLSGYANADNIETLGKDELGDYL
GTLSVSTMRLVNDALAVALALAPTRTQQPDTSQ

Download         Length: 342 bp

>T227863 NZ_CP123204:c4976826-4976536 [Pseudomonas amygdali pv. aesculi]
ATGACCTATAACCTCGAATTCGATGCGCGGGCTCTAAAGGAATGGCACAAATTAGGAGATACCGTGCGTCAGCAGCTCAA
GAAAAAGCTGGCTACGATTCTGGTTGCTCCGCGTGTTGAAGCCAATCGTCTGCATGCATTGCCTGACTGCTACAAAATCA
AACTGCGCAGTAGCGGCTATCGGCTGGTTTATCAGGTTATTGACCAAGAGGTTGTGGTCTTCGTGGTTGCGGTAGACAAG
CGTGAACGGGAAGAGGTTTATCGCAAGGCGACGGACCGGCTGGGTAGGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10175.14 Da        Isoelectric Point: 5.1976

>AT227863 WP_075513612.1 NZ_CP089224:c4618969-4618700 [Mycobacterium ostraviense]
MTAEYSTRLRLDEPTRQRLEDLVSAGHYRSGNAAIVDAINRLWEALRDEDLDAAYAAAVEDNPHYPYESEVERATARRRR
NARQKAAAE

Download         Length: 270 bp

>AT227863 NZ_CP123204:c4977055-4976816 [Pseudomonas amygdali pv. aesculi]
ATGGCGTCTATCAACGTTCGTATCGACGACGATCTCAAAGCGCGTGCTTACCTCGAGCTGGAAAAGCTTGGCGTCACCCC
CTCGGAGTTGCTGCGCCAAACCCTGCAGTACGTAGCTGAGCGTGGTCAGCTACCCTTCAAGACGGTTCTGATGACAGAGG
AAGACGAAGCGCTGTTGGCAACTGTGCGCGAGCGCCTTGCAGCTCCGCAGCGGGTCAAGGTTTCACTGGATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A163T172

Antitoxin

Source ID Structure
AlphaFold DB A0A163T159

References