227861

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3421792..3422467 Replicon chromosome
Accession NZ_CP089224
Organism Mycobacterium ostraviense strain FDAARGOS_1613

Toxin (Protein)


Gene name vapC Uniprot ID A0A163RPJ2
Locus tag LTS72_RS15555 Protein ID WP_075513736.1
Coordinates 3422036..3422467 (+) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A163RPK4
Locus tag LTS72_RS15550 Protein ID WP_075513737.1
Coordinates 3421792..3422049 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LTS72_RS15530 (LTS72_15530) 3417111..3417968 - 858 WP_075513741.1 GNAT family N-acetyltransferase -
LTS72_RS15535 (LTS72_15535) 3418022..3419206 - 1185 WP_099318810.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
LTS72_RS15540 (LTS72_15540) 3419230..3420444 - 1215 WP_075513739.1 M50 family metallopeptidase -
LTS72_RS15545 (LTS72_15545) 3420464..3421672 - 1209 WP_075513738.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
LTS72_RS15550 (LTS72_15550) 3421792..3422049 + 258 WP_075513737.1 ribbon-helix-helix domain-containing protein Antitoxin
LTS72_RS15555 (LTS72_15555) 3422036..3422467 + 432 WP_075513736.1 type II toxin-antitoxin system VapC family toxin Toxin
LTS72_RS15560 (LTS72_15560) 3422609..3422863 + 255 WP_075513735.1 DUF2631 domain-containing protein -
LTS72_RS15565 (LTS72_15565) 3422856..3423722 - 867 WP_075513782.1 cytochrome c biogenesis CcdA family protein -
LTS72_RS15570 (LTS72_15570) 3423727..3424248 - 522 WP_075513734.1 protein disulfide oxidoreductase -
LTS72_RS15575 (LTS72_15575) 3424436..3425530 - 1095 WP_075513733.1 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN -
LTS72_RS15580 (LTS72_15580) 3425571..3426458 - 888 WP_075513732.1 phosphatidate cytidylyltransferase -
LTS72_RS15585 (LTS72_15585) 3426490..3427047 - 558 WP_075513731.1 ribosome recycling factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-133)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 16188.38 Da        Isoelectric Point: 7.0619

>T227861 WP_075513736.1 NZ_CP089224:3422036-3422467 [Mycobacterium ostraviense]
MLCVDVNVLVYAHRADLREHSSYRSLLERLANDDEPLGLPDGALAGFVRAVTNRRVFTEPTSPHDAWQAVHALLAAPAAV
RLRPGERHWMLFRQLVADIDASGNDIVDAYLAAYALENNATWVSADRGFARFRRLRWRHPLDM

Download         Length: 432 bp

>T227861 NZ_CP123197:4623994-4624521 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATAAAAAAGCCCATACGTTTTATCAATCGCTGGGCTTTATCCCGTTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATCGAACTGCTTTTCACACAGAGCGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9115.28 Da        Isoelectric Point: 9.9597

>AT227861 WP_075513737.1 NZ_CP089224:3421792-3422049 [Mycobacterium ostraviense]
MRTTIRIDDELYREVKARAARSGRTVAAVLEDAVRRGLNPPEQPAAGRYRVQPTGRGGLRPGVDLSANAAVAEAMDEGVS
VDALR

Download         Length: 258 bp

>AT227861 NZ_CP123197:4623721-4623987 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCTGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A163RPJ2

Antitoxin

Source ID Structure
AlphaFold DB A0A163RPK4

References