Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 1328247..1328880 Replicon chromosome
Accession NC_010552
Organism Burkholderia ambifaria MC40-6

Toxin (Protein)


Gene name vapC Uniprot ID B1YWM3
Locus tag BAMMC406_RS21470 Protein ID WP_012366058.1
Coordinates 1328467..1328880 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B1YWM2
Locus tag BAMMC406_RS21465 Protein ID WP_012366057.1
Coordinates 1328247..1328480 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BAMMC406_RS21450 1323291..1324982 + 1692 WP_041490036.1 VRR-NUC domain-containing protein -
BAMMC406_RS21455 1324979..1327279 + 2301 WP_012366055.1 ATP-dependent DNA helicase -
BAMMC406_RS21460 1327319..1328089 - 771 WP_012366056.1 helix-turn-helix domain-containing protein -
BAMMC406_RS21465 1328247..1328480 + 234 WP_012366057.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BAMMC406_RS21470 1328467..1328880 + 414 WP_012366058.1 PIN domain-containing protein Toxin
BAMMC406_RS21475 1329095..1330396 - 1302 WP_012366059.1 UDP-N-acetylglucosamine 1-carboxyvinyltransferase -
BAMMC406_RS21480 1330607..1331914 - 1308 WP_011658812.1 shikimate transporter -
BAMMC406_RS21485 1332268..1333395 + 1128 WP_012366060.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(10-119)

Antitoxin

SpoVT-AbrB domain

(5-37)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15332.53 Da        Isoelectric Point: 4.9438

>T22786 WP_012366058.1 NC_010552:1328467-1328880 [Burkholderia ambifaria MC40-6]
MSGIEPAKSFVDSNVVLYLLSEDETKANRAEALFLRRPTISVQVLNEVASVCSRKLRMPWSDIGQFLEPIRSLCQVVPIT
VDTHDLARRLAERHGFSFYDACIVATASIEGCEYLYTEDMHDGLRVEGGPVLRNPFA

Download         Length: 414 bp

>T22786 NC_010552:1328467-1328880 [Burkholderia ambifaria MC40-6]
ATGAGCGGGATTGAGCCGGCGAAATCGTTCGTCGACAGCAATGTCGTGCTTTATCTGCTGTCCGAGGACGAGACCAAGGC
GAATCGTGCGGAGGCGCTGTTCCTTCGGCGGCCGACCATCAGCGTTCAGGTACTCAACGAAGTTGCCAGCGTTTGCAGCC
GCAAATTGCGCATGCCGTGGAGCGACATAGGGCAGTTTCTGGAGCCGATCAGGAGTTTGTGCCAGGTCGTCCCGATCACG
GTGGACACGCATGACCTGGCGCGAAGGCTGGCGGAGCGGCACGGTTTCTCTTTCTACGACGCATGCATCGTGGCAACCGC
TTCGATCGAGGGCTGCGAATACCTGTACACGGAGGACATGCACGACGGCTTGCGCGTGGAGGGTGGTCCGGTGTTGCGAA
ATCCGTTTGCCTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8835.07 Da        Isoelectric Point: 8.8306

>AT22786 WP_012366057.1 NC_010552:1328247-1328480 [Burkholderia ambifaria MC40-6]
MQVAKWGNSLAVRLPASVVDALELREGDDIEIVVDSPRVFAVSRKPRPDELLQRLRRFRGKLPADFKFSRDDANERD

Download         Length: 234 bp

>AT22786 NC_010552:1328247-1328480 [Burkholderia ambifaria MC40-6]
ATGCAGGTTGCAAAGTGGGGCAATAGCCTGGCGGTCCGCCTGCCGGCCAGCGTGGTCGATGCACTCGAGCTCCGCGAGGG
AGACGACATCGAAATCGTGGTTGACAGCCCCCGCGTTTTCGCGGTGAGCCGCAAGCCGCGGCCCGACGAACTTCTGCAGC
GGTTGAGGCGTTTCCGGGGCAAGCTGCCCGCTGACTTCAAGTTCAGCCGGGACGACGCAAATGAGCGGGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B1YWM3

Antitoxin

Source ID Structure
AlphaFold DB A0A3N7ZAY4

References