Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-PHD |
| Location | 3019091..3019776 | Replicon | chromosome |
| Accession | NZ_CP089224 | ||
| Organism | Mycobacterium ostraviense strain FDAARGOS_1613 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | A0A163UK78 |
| Locus tag | LTS72_RS13620 | Protein ID | WP_075513409.1 |
| Coordinates | 3019091..3019501 (-) | Length | 137 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | A0A163UK93 |
| Locus tag | LTS72_RS13625 | Protein ID | WP_075513410.1 |
| Coordinates | 3019498..3019776 (-) | Length | 93 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LTS72_RS13595 (LTS72_13595) | 3014924..3015688 | + | 765 | WP_099318765.1 | B-4DMT family transporter | - |
| LTS72_RS13600 (LTS72_13600) | 3015685..3016125 | - | 441 | WP_075513405.1 | type II 3-dehydroquinate dehydratase | - |
| LTS72_RS13605 (LTS72_13605) | 3016122..3017210 | - | 1089 | WP_075513406.1 | 3-dehydroquinate synthase | - |
| LTS72_RS13610 (LTS72_13610) | 3017207..3017743 | - | 537 | WP_075513407.1 | shikimate kinase | - |
| LTS72_RS13615 (LTS72_13615) | 3017761..3018966 | - | 1206 | WP_075513408.1 | chorismate synthase | - |
| LTS72_RS13620 (LTS72_13620) | 3019091..3019501 | - | 411 | WP_075513409.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| LTS72_RS13625 (LTS72_13625) | 3019498..3019776 | - | 279 | WP_075513410.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| LTS72_RS13630 (LTS72_13630) | 3019835..3020269 | - | 435 | WP_075513416.1 | A24 family peptidase | - |
| LTS72_RS13635 (LTS72_13635) | 3020287..3021111 | - | 825 | WP_075513411.1 | shikimate dehydrogenase | - |
| LTS72_RS13640 (LTS72_13640) | 3021089..3022336 | - | 1248 | WP_075513412.1 | endolytic transglycosylase MltG | - |
| LTS72_RS13645 (LTS72_13645) | 3022329..3022841 | - | 513 | WP_075513413.1 | Holliday junction resolvase RuvX | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 137 a.a. Molecular weight: 14710.98 Da Isoelectric Point: 5.6445
>T227859 WP_075513409.1 NZ_CP089224:c3019501-3019091 [Mycobacterium ostraviense]
VIYLDTSALTKLLIAEPETADLRSWLTSQREQGEFAATSALGRVELMRVVARYGDPAHVERARYLLDGLDILPLTAPVMN
LAETIGPATLRSLDAIHLAAATQIKRELSAFVTYDHRLLAGCLEVGLVTASPGAVR
VIYLDTSALTKLLIAEPETADLRSWLTSQREQGEFAATSALGRVELMRVVARYGDPAHVERARYLLDGLDILPLTAPVMN
LAETIGPATLRSLDAIHLAAATQIKRELSAFVTYDHRLLAGCLEVGLVTASPGAVR
Download Length: 411 bp
>T227859 NZ_CP123197:c3910746-3910198 [Escherichia coli]
ATGTCTCATAATTCAGATATCTATAAACTGATCGGAGCGGCCGCAGGTGTTGAAAATGGTCGCTCTGAAGCATCCTTAAA
CTCTACTGACAGTCAAGAGCAGGCTTTTGAATCCGCATTTGAGCCGTCTAATCATGAACGCGATGATGATTCTTCTTCAG
AAAATAAGGCTATTCTGGAGGAAGAAGAGTTTGGTTCTAATACTGGTGCATTGCATGAGTTTATGCAGCAGAACAGAATG
GACAGTCTTCAAGCTCAGCTTGATATGCTCAAATCACAAGTACGGGATAAGATAGCTGACGCAACTGGTAAAGAAATAGA
CAATGAGCTCCGGACAAAAATGGCATCATTCACGGTTTGGTTTATGTCGTGTTGGTGCTTATTCGTTGTCGCAATGTTTA
CATCGTTTCTTATTGCACATGAAGGAAAGGCTCCAGTTGAAGCGATCGTTGCATTACTAGGTACAAGTACAATTAGTATT
GTTGGTTTGGTTGGTTTCGTTGTTAGTGGATTGTTCAAATCAAGAAAAGATAGTGATAAAGAAAAATAA
ATGTCTCATAATTCAGATATCTATAAACTGATCGGAGCGGCCGCAGGTGTTGAAAATGGTCGCTCTGAAGCATCCTTAAA
CTCTACTGACAGTCAAGAGCAGGCTTTTGAATCCGCATTTGAGCCGTCTAATCATGAACGCGATGATGATTCTTCTTCAG
AAAATAAGGCTATTCTGGAGGAAGAAGAGTTTGGTTCTAATACTGGTGCATTGCATGAGTTTATGCAGCAGAACAGAATG
GACAGTCTTCAAGCTCAGCTTGATATGCTCAAATCACAAGTACGGGATAAGATAGCTGACGCAACTGGTAAAGAAATAGA
CAATGAGCTCCGGACAAAAATGGCATCATTCACGGTTTGGTTTATGTCGTGTTGGTGCTTATTCGTTGTCGCAATGTTTA
CATCGTTTCTTATTGCACATGAAGGAAAGGCTCCAGTTGAAGCGATCGTTGCATTACTAGGTACAAGTACAATTAGTATT
GTTGGTTTGGTTGGTTTCGTTGTTAGTGGATTGTTCAAATCAAGAAAAGATAGTGATAAAGAAAAATAA
Antitoxin
Download Length: 93 a.a. Molecular weight: 10201.56 Da Isoelectric Point: 5.8900
>AT227859 WP_075513410.1 NZ_CP089224:c3019776-3019498 [Mycobacterium ostraviense]
VEVIGVRELRQHASRYLARVEAGEELGITNNGRLVARLVPVRAAERSREALIESGAVIAAPRPQNLFEVTATPAPDRKRT
LSDVLDEMRDEQ
VEVIGVRELRQHASRYLARVEAGEELGITNNGRLVARLVPVRAAERSREALIESGAVIAAPRPQNLFEVTATPAPDRKRT
LSDVLDEMRDEQ
Download Length: 279 bp
>AT227859 NZ_CP123197:c3911242-3910769 [Escherichia coli]
ATGTACAGTCCGGTACAAATAGCCAATAAATTCATAACGTTGGGAAACCAACATCATAATCCTCTGACCCACATGCAACT
GCAGAAGCTTACTTATATTGCCCATGGTTACTATTTAGCATTAACAGGTAAGCCTTTGCTCAATGAATGTGTCTCCGCGT
GGAAGTACGGTCCAGTTATTCCTGGAATGTACGATGCTTTCAAAGACTATGGGAATAAACCTGTTACGAATGTAGCAGTA
GCTCCTTTTGGTGGCATCGTTACTATGGATCCGCAAGCAGAGAGCATTATCGGGGCTGTTTATAAGTTTTACGGCTCGAA
AAATGGAATTGAGTTATCAACTCTAACTCATATGCCAGGTACGCCTTGGTCACAAGCTTATAATGGTATTGGCTCGTCGA
TCATCTCAAATGATGCGATCAAGGCTTATTATCATGATTTATTGAATAACCGACAGCAATGTCAGGGCCTCTGA
ATGTACAGTCCGGTACAAATAGCCAATAAATTCATAACGTTGGGAAACCAACATCATAATCCTCTGACCCACATGCAACT
GCAGAAGCTTACTTATATTGCCCATGGTTACTATTTAGCATTAACAGGTAAGCCTTTGCTCAATGAATGTGTCTCCGCGT
GGAAGTACGGTCCAGTTATTCCTGGAATGTACGATGCTTTCAAAGACTATGGGAATAAACCTGTTACGAATGTAGCAGTA
GCTCCTTTTGGTGGCATCGTTACTATGGATCCGCAAGCAGAGAGCATTATCGGGGCTGTTTATAAGTTTTACGGCTCGAA
AAATGGAATTGAGTTATCAACTCTAACTCATATGCCAGGTACGCCTTGGTCACAAGCTTATAATGGTATTGGCTCGTCGA
TCATCTCAAATGATGCGATCAAGGCTTATTATCATGATTTATTGAATAACCGACAGCAATGTCAGGGCCTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A163UK78 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A163UK93 |