227857

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 1656015..1656579 Replicon chromosome
Accession NZ_CP089224
Organism Mycobacterium ostraviense strain FDAARGOS_1613

Toxin (Protein)


Gene name relE Uniprot ID A0A162FRQ0
Locus tag LTS72_RS07625 Protein ID WP_075509224.1
Coordinates 1656298..1656579 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A162D5E9
Locus tag LTS72_RS07620 Protein ID WP_075509223.1
Coordinates 1656015..1656296 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LTS72_RS07590 (LTS72_07590) 1651906..1652796 - 891 WP_233027019.1 adenylate/guanylate cyclase domain-containing protein -
LTS72_RS07595 (LTS72_07595) 1652988..1653308 + 321 WP_075509221.1 hypothetical protein -
LTS72_RS07600 (LTS72_07600) 1653585..1654286 + 702 WP_075509226.1 haloacid dehalogenase type II -
LTS72_RS07605 (LTS72_07605) 1654503..1654835 - 333 WP_075509222.1 DUF202 domain-containing protein -
LTS72_RS07610 (LTS72_07610) 1654832..1655221 - 390 WP_036416545.1 DUF202 domain-containing protein -
LTS72_RS07615 (LTS72_07615) 1655561..1655954 + 394 Protein_1506 IS607 family transposase -
LTS72_RS07620 (LTS72_07620) 1656015..1656296 + 282 WP_075509223.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LTS72_RS07625 (LTS72_07625) 1656298..1656579 + 282 WP_075509224.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LTS72_RS07630 (LTS72_07630) 1656891..1657418 - 528 WP_075509225.1 hypothetical protein -
LTS72_RS07635 (LTS72_07635) 1657537..1659150 - 1614 WP_083044372.1 hypothetical protein -
LTS72_RS07640 (LTS72_07640) 1659467..1660349 - 883 Protein_1511 IS1380 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1655630..1655944 314


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(11-90)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10810.17 Da        Isoelectric Point: 10.2285

>T227857 WP_075509224.1 NZ_CP089224:1656298-1656579 [Mycobacterium ostraviense]
VANSDDVYTTRFTATGKRDLDKLPPRIFAAVIEFAFGDLAREPRRVGKPLGRDLANHHSARRGPYRLLYRIDDEAQTIWV
HRVDHRSDVYRHP

Download         Length: 282 bp

>T227857 NZ_CP123197:2967746-2967964 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTTTGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10413.63 Da        Isoelectric Point: 4.6388

>AT227857 WP_075509223.1 NZ_CP089224:1656015-1656296 [Mycobacterium ostraviense]
MRVIPVTQVKAKINEYVDAVRDTRDQITITKNGAPAAVLIGVDEWESIQETLHWLSQPGVAESVQQSEADIAAGRTYGED
EIRAEYQVPRRPH

Download         Length: 282 bp

>AT227857 NZ_CP123197:2967346-2967720 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A162FRQ0

Antitoxin

Source ID Structure
AlphaFold DB A0A162D5E9

References