Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-PHD |
| Location | 2501391..2502052 | Replicon | chromosome |
| Accession | NZ_CP089223 | ||
| Organism | Mycobacterium avium subsp. avium strain FDAARGOS_1609 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | A0A049E7F1 |
| Locus tag | LTQ57_RS11750 | Protein ID | WP_023879930.1 |
| Coordinates | 2501391..2501795 (-) | Length | 135 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | A0A049EBE1 |
| Locus tag | LTQ57_RS11755 | Protein ID | WP_009976405.1 |
| Coordinates | 2501792..2502052 (-) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LTQ57_RS11725 (LTQ57_11725) | 2496570..2497739 | + | 1170 | WP_009976416.1 | acyl-CoA dehydrogenase | - |
| LTQ57_RS11730 (LTQ57_11730) | 2497728..2498258 | - | 531 | WP_011724637.1 | TetR/AcrR family transcriptional regulator | - |
| LTQ57_RS11735 (LTQ57_11735) | 2498379..2498924 | - | 546 | WP_009976412.1 | carboxymuconolactone decarboxylase family protein | - |
| LTQ57_RS11740 (LTQ57_11740) | 2498921..2499442 | - | 522 | WP_009976411.1 | carboxymuconolactone decarboxylase family protein | - |
| LTQ57_RS11745 (LTQ57_11745) | 2499679..2501244 | + | 1566 | WP_029248458.1 | serine/threonine-protein kinase | - |
| LTQ57_RS11750 (LTQ57_11750) | 2501391..2501795 | - | 405 | WP_023879930.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| LTQ57_RS11755 (LTQ57_11755) | 2501792..2502052 | - | 261 | WP_009976405.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
| LTQ57_RS11760 (LTQ57_11760) | 2502233..2502685 | - | 453 | WP_029248457.1 | VOC family protein | - |
| LTQ57_RS11765 (LTQ57_11765) | 2502851..2504119 | + | 1269 | WP_023884275.1 | cytochrome P450 | - |
| LTQ57_RS11770 (LTQ57_11770) | 2504321..2505781 | - | 1461 | WP_009976402.1 | serine/threonine-protein kinase | - |
| LTQ57_RS11775 (LTQ57_11775) | 2505976..2506638 | - | 663 | WP_009976400.1 | TetR/AcrR family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 135 a.a. Molecular weight: 14329.33 Da Isoelectric Point: 4.5860
>T227852 WP_023879930.1 NZ_CP089223:c2501795-2501391 [Mycobacterium avium subsp. avium]
MTARPAGVLDTSVFIASESGRHLDEARIPDEVATTVITLAELHAGVLAATTSDVRAQRLATLESIADMEMLPVDDDAARM
WARLRIHLAEAGRRMRANDLWIAGIAASRGLPVVTQDDDFAALDGAANLAIIRV
MTARPAGVLDTSVFIASESGRHLDEARIPDEVATTVITLAELHAGVLAATTSDVRAQRLATLESIADMEMLPVDDDAARM
WARLRIHLAEAGRRMRANDLWIAGIAASRGLPVVTQDDDFAALDGAANLAIIRV
Download Length: 405 bp
>T227852 NZ_CP123197:c1331117-1330743 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9495.81 Da Isoelectric Point: 11.4633
>AT227852 WP_009976405.1 NZ_CP089223:c2502052-2501792 [Mycobacterium avium subsp. avium]
MSEVASRELRNDTAGVLRRVREGEDVTITVNGRAVAMLTALGPQRRRWLSKAELLSRLRRAQADPGLRQDLATLAGDTTE
DLGPIR
MSEVASRELRNDTAGVLRRVREGEDVTITVNGRAVAMLTALGPQRRRWLSKAELLSRLRRAQADPGLRQDLATLAGDTTE
DLGPIR
Download Length: 261 bp
>AT227852 NZ_CP123197:c1331574-1331206 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A049E7F1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A049EBE1 |