Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/ParD(antitoxin)
Location 1986346..1987344 Replicon chromosome
Accession NZ_CP089223
Organism Mycobacterium avium subsp. avium strain FDAARGOS_1609

Toxin (Protein)


Gene name pezT Uniprot ID X7VT18
Locus tag LTQ57_RS09280 Protein ID WP_003876749.1
Coordinates 1986346..1986924 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID A0A049EEK5
Locus tag LTQ57_RS09285 Protein ID WP_009976725.1
Coordinates 1986955..1987344 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LTQ57_RS09255 (LTQ57_09255) 1982341..1983270 - 930 Protein_1832 sigma-70 family RNA polymerase sigma factor -
LTQ57_RS09260 (LTQ57_09260) 1983439..1983789 + 351 WP_003878038.1 DoxX family protein -
LTQ57_RS09265 (LTQ57_09265) 1983803..1984603 - 801 WP_009976729.1 nuclear transport factor 2 family protein -
LTQ57_RS09270 (LTQ57_09270) 1984603..1985163 - 561 WP_155251422.1 pyrazinamidase PncA -
LTQ57_RS09275 (LTQ57_09275) 1985274..1986341 + 1068 WP_003876748.1 DoxX family protein -
LTQ57_RS09280 (LTQ57_09280) 1986346..1986924 - 579 WP_003876749.1 zeta toxin family protein Toxin
LTQ57_RS09285 (LTQ57_09285) 1986955..1987344 - 390 WP_009976725.1 hypothetical protein Antitoxin
LTQ57_RS09290 (LTQ57_09290) 1987425..1987919 - 495 WP_009976723.1 gluconokinase -
LTQ57_RS09295 (LTQ57_09295) 1987916..1989913 - 1998 WP_009976721.1 phosphotransferase -
LTQ57_RS09300 (LTQ57_09300) 1989932..1991449 - 1518 WP_009976720.1 carboxylesterase/lipase family protein -
LTQ57_RS09305 (LTQ57_09305) 1991528..1992208 + 681 WP_023861532.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(5-136)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21034.18 Da        Isoelectric Point: 10.6678

>T227851 WP_003876749.1 NZ_CP089223:c1986924-1986346 [Mycobacterium avium subsp. avium]
MERLDVVVGPNGAGKSTFIALTLAPLLPGSVVVNADEIARQRWPQDPASHAYDAAKVAADTRAKLIDLGRSFIAETVFSH
PSKLDLLHAARRAGFTVVLHVLLIPEDLAVERVRHRVRAGGHDVPETKIRERHRRLWTPVAEAMTLADLATGYDNSRLRG
PRVVARLSGGLTVGAVDWPAWAPETLRSRWPV

Download         Length: 579 bp

>T227851 NZ_CP123197:1319221-1319475 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13598.04 Da        Isoelectric Point: 5.6717

>AT227851 WP_009976725.1 NZ_CP089223:c1987344-1986955 [Mycobacterium avium subsp. avium]
MAEAVDRVTRVASDLMDSAAAEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGRLSTAELTVEEGVVFNAEI
SAAIDESLARTNYGATLAGQGVTTVALNDDGEIVEHRPDGTAVVLAGRR

Download         Length: 390 bp

>AT227851 NZ_CP123197:1318973-1319224 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E2W6B4

Antitoxin

Source ID Structure
AlphaFold DB A0A049EEK5

References