Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 970833..971479 Replicon chromosome
Accession NC_010552
Organism Burkholderia ambifaria MC40-6

Toxin (Protein)


Gene name vapC Uniprot ID B1Z2J7
Locus tag BAMMC406_RS19950 Protein ID WP_012365790.1
Coordinates 971072..971479 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q0BA09
Locus tag BAMMC406_RS19945 Protein ID WP_011658485.1
Coordinates 970833..971075 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BAMMC406_RS19930 966833..968239 + 1407 WP_012365787.1 aspartate ammonia-lyase -
BAMMC406_RS19935 968343..969836 + 1494 WP_012365788.1 amino acid permease -
BAMMC406_RS19940 969880..970569 - 690 WP_012365789.1 phospholipase -
BAMMC406_RS19945 970833..971075 + 243 WP_011658485.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BAMMC406_RS19950 971072..971479 + 408 WP_012365790.1 type II toxin-antitoxin system VapC family toxin Toxin
BAMMC406_RS19955 971975..974365 + 2391 WP_012365791.1 MCP four helix bundle domain-containing protein -
BAMMC406_RS19960 974368..975108 + 741 WP_012365792.1 chemotaxis protein -
BAMMC406_RS19965 975105..975689 + 585 WP_012365793.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14835.85 Da        Isoelectric Point: 5.9828

>T22785 WP_012365790.1 NC_010552:971072-971479 [Burkholderia ambifaria MC40-6]
MKFLLDTNAVIAILKGEQAMLARLRTHQPADFGIPAIVAHELYYGAYKSQRAAANLARVEGLQFEVVSFDAEDAQHAGEI
RAQLAAVGTPIGPYDALIAGQARARRLVLVTHNTREFERVSELQVEDWLAAAHEN

Download         Length: 408 bp

>T22785 NC_010552:971072-971479 [Burkholderia ambifaria MC40-6]
ATGAAGTTTCTGCTGGATACCAATGCGGTAATCGCCATTCTGAAAGGCGAACAGGCCATGCTGGCCCGCTTGCGTACACA
TCAACCTGCGGATTTCGGAATTCCCGCGATCGTCGCGCATGAACTCTATTACGGGGCGTACAAGAGTCAGAGAGCGGCAG
CGAATCTGGCACGCGTCGAGGGGCTTCAGTTCGAGGTCGTGTCGTTCGATGCGGAAGATGCTCAGCATGCCGGGGAAATC
CGTGCGCAACTGGCCGCGGTGGGAACACCGATCGGGCCATACGATGCATTGATCGCAGGACAGGCGCGAGCGCGACGCCT
GGTGCTTGTCACGCACAACACGCGCGAGTTTGAGCGGGTCTCGGAGCTGCAGGTCGAGGATTGGCTCGCGGCGGCGCACG
AAAACTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8872.03 Da        Isoelectric Point: 4.7628

>AT22785 WP_011658485.1 NC_010552:970833-971075 [Burkholderia ambifaria MC40-6]
METAKIFKHGGSQAVRLPKDFRFDTTEVRIRRHGASVILEPVPQDWAWLTPLIGPVDADFEAAAATEPAAQERPGLDVFE

Download         Length: 243 bp

>AT22785 NC_010552:970833-971075 [Burkholderia ambifaria MC40-6]
ATGGAGACTGCCAAGATTTTCAAGCATGGTGGATCGCAGGCCGTCCGCTTGCCGAAGGATTTCCGCTTCGATACAACGGA
GGTCCGGATTCGTCGGCACGGCGCGTCTGTCATTCTCGAACCGGTGCCGCAAGACTGGGCATGGTTGACACCGTTGATCG
GCCCCGTTGACGCCGATTTCGAGGCCGCCGCGGCAACCGAGCCTGCCGCTCAAGAGCGTCCAGGGCTGGACGTGTTTGAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B1Z2J7

Antitoxin

Source ID Structure
AlphaFold DB A0A3P0NDJ4

References