Detailed information of TA system TA227849

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/ParD(antitoxin)
• Location: 1476771..1477763
• Replicon: chromosome
• Accession: NZ_CP089222
• Organism: Mycobacterium intracellulare subsp. intracellulare strain FDAARGOS_1610

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: LTQ56_RS06610
• Protein ID: WP_009956379.1
• Coordinates: 1477185..1477763 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: A0A7I7TS83
• Locus tag: LTQ56_RS06605
• Protein ID: WP_009956380.1
• Coordinates: 1476771..1477160 (+)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LTQ56_RS06580 (LTQ56_06580)	1472223..1474226	+	2004	WP_009956386.1	phosphotransferase	-
LTQ56_RS06585 (LTQ56_06585)	1474223..1474768	+	546	WP_044059213.1	gluconokinase	-
LTQ56_RS06590 (LTQ56_06590)	1474792..1475403	-	612	WP_009956383.1	TetR/AcrR family transcriptional regulator	-
LTQ56_RS06595 (LTQ56_06595)	1475439..1476398	+	960	WP_225331100.1	SAM-dependent methyltransferase	-
LTQ56_RS06600 (LTQ56_06600)	1476426..1476713	+	288	WP_225332075.1	hypothetical protein	-
LTQ56_RS06605 (LTQ56_06605)	1476771..1477160	+	390	WP_009956380.1	hypothetical protein	Antitoxin
LTQ56_RS06610 (LTQ56_06610)	1477185..1477763	+	579	WP_009956379.1	zeta toxin family protein	Toxin
LTQ56_RS06615 (LTQ56_06615)	1477783..1478850	-	1068	WP_036397470.1	DoxX family protein	-
LTQ56_RS06620 (LTQ56_06620)	1478946..1479506	+	561	WP_029385272.1	pyrazinamidase PncA	-
LTQ56_RS06625 (LTQ56_06625)	1479506..1480306	+	801	WP_009956375.1	nuclear transport factor 2 family protein	-
LTQ56_RS06630 (LTQ56_06630)	1480318..1480668	-	351	WP_009956374.1	DoxX family protein	-
LTQ56_RS06635 (LTQ56_06635)	1480834..1481805	+	972	WP_029385267.1	sigma-70 family RNA polymerase sigma factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (4-136)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 20962.05 Da
• Isoelectric Point: 11.0233

>T227849 WP_009956379.1 NZ_CP089222:1477185-1477763 [Mycobacterium intracellulare subsp. intracellulare]
MQRLDLVVGPNGAGKSTFIAFTLAPLLPGSPVVNADEIARQRWPGEAAGRAYDAAQIAAATRAKLIDLGRSFIAETVFSH
PSKLDLVRTAHRAGFTAVLHAMLIPEDLAVERVRHRVRAGGHDVPETKVRERHRRLWTPVTDAIALSDVATVYDSGRLRG
PRIVARLSGGMTIGSPDWPAWAPEILRSRWPD

Nucleotide

• Length: 579 bp

>T227849 NZ_CP123197:828997-829395 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 13512.89 Da
• Isoelectric Point: 5.1828

>AT227849 WP_009956380.1 NZ_CP089222:1476771-1477160 [Mycobacterium intracellulare subsp. intracellulare]
MADAPDRVTRVASDLMDSAASEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGQLATGELTVEEGVVFNAEI
SAAIEESLVHADYGATLAGHGVTTVALNEDGDIVEHRPDGAAVVLARGR

Nucleotide

• Length: 390 bp

>AT227849 NZ_CP123197:828770-828997 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA

Structures

Antitoxin

• AlphaFold DB: A0A7I7TS83