Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/ParD(antitoxin)
Location 2083342..2084334 Replicon chromosome
Accession NZ_CP089220
Organism Mycobacterium intracellulare strain FDAARGOS_1612

Toxin (Protein)


Gene name pezT Uniprot ID -
Locus tag LTQ55_RS09525 Protein ID WP_009956379.1
Coordinates 2083756..2084334 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID A0A7I7TS83
Locus tag LTQ55_RS09520 Protein ID WP_009956380.1
Coordinates 2083342..2083731 (+) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LTQ55_RS09495 (LTQ55_09495) 2078794..2080797 + 2004 WP_009956386.1 phosphotransferase -
LTQ55_RS09500 (LTQ55_09500) 2080794..2081339 + 546 WP_044059213.1 gluconokinase -
LTQ55_RS09505 (LTQ55_09505) 2081363..2081974 - 612 WP_009956383.1 TetR/AcrR family transcriptional regulator -
LTQ55_RS09510 (LTQ55_09510) 2082010..2082969 + 960 WP_225331100.1 SAM-dependent methyltransferase -
LTQ55_RS09515 (LTQ55_09515) 2082997..2083284 + 288 WP_225332075.1 hypothetical protein -
LTQ55_RS09520 (LTQ55_09520) 2083342..2083731 + 390 WP_009956380.1 hypothetical protein Antitoxin
LTQ55_RS09525 (LTQ55_09525) 2083756..2084334 + 579 WP_009956379.1 zeta toxin family protein Toxin
LTQ55_RS09530 (LTQ55_09530) 2084354..2085421 - 1068 WP_036397470.1 DoxX family protein -
LTQ55_RS09535 (LTQ55_09535) 2085517..2086077 + 561 WP_029385272.1 pyrazinamidase PncA -
LTQ55_RS09540 (LTQ55_09540) 2086077..2086877 + 801 WP_009956375.1 nuclear transport factor 2 family protein -
LTQ55_RS09545 (LTQ55_09545) 2086889..2087239 - 351 WP_009956374.1 DoxX family protein -
LTQ55_RS09550 (LTQ55_09550) 2087405..2088376 + 972 WP_029385267.1 sigma-70 family RNA polymerase sigma factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-136)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 20962.05 Da        Isoelectric Point: 11.0233

>T227843 WP_009956379.1 NZ_CP089220:2083756-2084334 [Mycobacterium intracellulare]
MQRLDLVVGPNGAGKSTFIAFTLAPLLPGSPVVNADEIARQRWPGEAAGRAYDAAQIAAATRAKLIDLGRSFIAETVFSH
PSKLDLVRTAHRAGFTAVLHAMLIPEDLAVERVRHRVRAGGHDVPETKVRERHRRLWTPVTDAIALSDVATVYDSGRLRG
PRIVARLSGGMTIGSPDWPAWAPEILRSRWPD

Download         Length: 579 bp

>T227843 NZ_CP123196:c109635-109486 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13512.89 Da        Isoelectric Point: 5.1828

>AT227843 WP_009956380.1 NZ_CP089220:2083342-2083731 [Mycobacterium intracellulare]
MADAPDRVTRVASDLMDSAASEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGQLATGELTVEEGVVFNAEI
SAAIEESLVHADYGATLAGHGVTTVALNEDGDIVEHRPDGAAVVLARGR

Download         Length: 390 bp

>AT227843 NZ_CP123196:109680-109739 [Escherichia coli]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7I7TS83

References