Detailed information of TA system TA227842

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-PHD
• Location: 1769500..1770164
• Replicon: chromosome
• Accession: NZ_CP089220
• Organism: Mycobacterium intracellulare strain FDAARGOS_1612

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: J9WD27
• Locus tag: LTQ55_RS08195
• Protein ID: WP_009954498.1
• Coordinates: 1769757..1770164 (+)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: LTQ55_RS08190
• Protein ID: WP_009954496.1
• Coordinates: 1769500..1769760 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LTQ55_RS08165 (LTQ55_08165)	1766008..1766499	-	492	WP_201368376.1	DUF1707 domain-containing protein	-
LTQ55_RS08170 (LTQ55_08170)	1766569..1767165	+	597	WP_201368381.1	TetR/AcrR family transcriptional regulator	-
LTQ55_RS08175 (LTQ55_08175)	1767170..1768438	-	1269	WP_201368375.1	cytochrome P450	-
LTQ55_RS08180 (LTQ55_08180)	1768599..1769051	+	453	WP_029384640.1	VOC family protein	-
LTQ55_RS08185 (LTQ55_08185)	1769088..1769327	+	240	WP_009954495.1	hypothetical protein	-
LTQ55_RS08190 (LTQ55_08190)	1769500..1769760	+	261	WP_009954496.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
LTQ55_RS08195 (LTQ55_08195)	1769757..1770164	+	408	WP_009954498.1	type II toxin-antitoxin system VapC family toxin	Toxin
LTQ55_RS08200 (LTQ55_08200)	1770342..1773443	+	3102	WP_009954499.1	DEAD/DEAH box helicase	-
LTQ55_RS08205 (LTQ55_08205)	1773505..1775070	-	1566	WP_009954500.1	protein kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (9-125)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-66)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 14293.28 Da
• Isoelectric Point: 4.2772

>T227842 WP_009954498.1 NZ_CP089220:1769757-1770164 [Mycobacterium intracellulare]
MSNPQVAGVLDTSVFIATESGRPLDAALIPDQVGTTVVTLAELHVGVLAASTSDIRAQRLATLESIADIEALPVDDDAAR
MWARLRIHLAETGQRVRINDLWIAAIAASRGLPVVTQDDDFAVLDGAANLTVIRV

Nucleotide

• Length: 408 bp

>T227842 NZ_CP123196:74096-74377 [Escherichia coli]
ATGACCTATGAACTGGCTTTTGACCGCAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAGCTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATATCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCTGTTGGAAGA
AGGGAAAGCAGCGAAGTTTATCAGATTGCAGATATGCGCTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9526.85 Da
• Isoelectric Point: 9.1203

>AT227842 WP_009954496.1 NZ_CP089220:1769500-1769760 [Mycobacterium intracellulare]
MSEVASRELRNDTAGVLRRVRDGEDVTITVSGRPVAVLTAVVPQRRRWLSKTELLSRLPRVQADPGLREDLHALAGDTTE
ELGPIR

Nucleotide

• Length: 261 bp

>AT227842 NZ_CP123196:73855-74106 [Escherichia coli]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Structures

Toxin

• AlphaFold DB: J9WD27