Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 748691..749235 Replicon chromosome
Accession NZ_CP089220
Organism Mycobacterium intracellulare strain FDAARGOS_1612

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag LTQ55_RS03630 Protein ID WP_233085930.1
Coordinates 748939..749235 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1X1TC43
Locus tag LTQ55_RS03625 Protein ID WP_066911550.1
Coordinates 748691..748942 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LTQ55_RS03610 (LTQ55_03610) 745384..746523 + 1140 WP_009953175.1 acyltransferase -
LTQ55_RS03615 (LTQ55_03615) 746645..747226 - 582 WP_008254688.1 TetR/AcrR family transcriptional regulator -
LTQ55_RS03620 (LTQ55_03620) 747226..748467 - 1242 WP_008254689.1 cytochrome P450 -
LTQ55_RS03625 (LTQ55_03625) 748691..748942 + 252 WP_066911550.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
LTQ55_RS03630 (LTQ55_03630) 748939..749235 + 297 WP_233085930.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LTQ55_RS03635 (LTQ55_03635) 749627..750505 + 879 WP_233085931.1 NlpC/P60 family protein -
LTQ55_RS03640 (LTQ55_03640) 750544..752064 + 1521 WP_233085932.1 type VII secretion protein EccB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin

Antitoxin ParD

(2-79)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11639.15 Da        Isoelectric Point: 6.4775

>T227841 WP_233085930.1 NZ_CP089220:748939-749235 [Mycobacterium intracellulare]
VKRYVLSPAARADLEQIWDYTCQRWDDDQAEEYVREIQRAIERVVDNPMIGRACDELRPGYRKHAVGSHTLYYRIVTGDV
INVVRILHQRMDVDRHLD

Download         Length: 297 bp

>T227841 NZ_CP123195:22277-22426 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9558.54 Da        Isoelectric Point: 7.0173

>AT227841 WP_066911550.1 NZ_CP089220:748691-748942 [Mycobacterium intracellulare]
VGKNTSFSLDEHYSAFIDEEVASGRYRSASDVVRSALRLLEDRETRLRALRQALDAGERSGEPTPFDFDEFVARKRAEQP
RRR

Download         Length: 252 bp

>AT227841 NZ_CP123195:c22233-22172 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1X1TC43

References