Detailed information of TA system TA227837

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): CapRel-ATcapRel/-
• Location: 4617448..4618352
• Replicon: chromosome
• Accession: NZ_CP089218
• Organism: Mycobacterium kansasii strain FDAARGOS_1614

Toxin (Protein)

• Gene name: capRel
• Uniprot ID: X7ZGG2
• Locus tag: LTT71_RS19995
• Protein ID: WP_023367202.1
• Coordinates: 4617699..4618352 (-)
• Length: 218 a.a.

Antitoxin (Protein)

• Gene name: ATcapRel
• Uniprot ID: X7ZF14
• Locus tag: LTT71_RS19990
• Protein ID: WP_023367200.1
• Coordinates: 4617448..4617702 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LTT71_RS19975 (LTT71_19975)	4613391..4614863	-	1473	WP_023367193.1	O-antigen ligase family protein	-
LTT71_RS19980 (LTT71_19980)	4614860..4616254	-	1395	WP_023367196.1	polysaccharide biosynthesis tyrosine autokinase	-
LTT71_RS19985 (LTT71_19985)	4616620..4617414	+	795	WP_036393567.1	FkbM family methyltransferase	-
LTT71_RS19990 (LTT71_19990)	4617448..4617702	-	255	WP_023367200.1	hypothetical protein	Antitoxin
LTT71_RS19995 (LTT71_19995)	4617699..4618352	-	654	WP_023367202.1	RelA/SpoT domain-containing protein	Toxin
LTT71_RS20005 (LTT71_20005)	4619609..4620754	-	1146	WP_036393847.1	hypothetical protein	-
LTT71_RS20010 (LTT71_20010)	4620942..4621595	-	654	WP_080674044.1	GNAT family protein	-
LTT71_RS20015 (LTT71_20015)	4621617..4622906	-	1290	WP_233013460.1	molybdopterin molybdotransferase MoeA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RelA/SpoT (53-150)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 218 a.a.
• Molecular weight: 24338.76 Da
• Isoelectric Point: 8.9815

>T227837 WP_023367202.1 NZ_CP089218:c4618352-4617699 [Mycobacterium kansasii]
VSTTIGPNEHGIEEIFQALDTLEAWRAAHARPLQAATMGLRSRVATMGCSQIEVSQRLERIPTIIDKLRREPGMNLGRMA
DIGGCRAVLRDVDEVRRVQSRYAGAAVTVRTRDYVEQPKSDGYRAVHVIVRYHGRLIEVQLRTQVQHEWAYTVESVTSRF
GLDIKAGGGPRPVHDWFVAVSEAMALEEYGEPVAPELLRRVDTLRAAAQPYLQGVRR

Nucleotide

• Length: 654 bp

>T227837 NZ_CP123056:c279061-278762 [Brucella intermedia]
ATGGTCCTTGAAACCACCCGTTTTGATGTTCTTGATCACCTCAAGACGCCGGAAGAGCGTGTTGCCTATCTGGAAGCGGC
ATTTGAAGATGGCGACCCTTCCCTTATTGCGCATGCTCTTGGTGACGTAGCCCGTTCCATTGGCATGACTACTGTCGCTA
AAGAAGCCGGAATTACCCGTGAAGCCCTTTACCGCTCCCTGAGCGAGAACGGCGATCCAAAACTATCGACCTTGCTCGGC
GTCATGAAGGCCCTTGGCCTGCACCTGTCTGTCACAGCCACGGATAAACGCGCCGCTTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9265.50 Da
• Isoelectric Point: 5.5094

>AT227837 WP_023367200.1 NZ_CP089218:c4617702-4617448 [Mycobacterium kansasii]
MTASLNHFLLVFDHSRAELVDLKNFGTDAKSAMAEYARLEREHMGKSDAIEIVLIGSDSLETVKVTHANYFDGTVAVSKY
FAGI

Nucleotide

• Length: 255 bp

>AT227837 NZ_CP123056:c279353-279063 [Brucella intermedia]
ATGATCGAAGTCCGCCAAACCACCTTTTTCACCAAGTGGCTTGATGAGCTCCGTGATACCAATGCACGGTTGCGGATTGT
CACTCGGATCCGCCGCATGGAACTGGGCAATCCCGGCGATGTGAAATCTGTCGGCGAAGGCGTGAGCGAAATGCGCATTA
CGTACGGCCCCGGCTATCGGGTTTATTTCGTATCCATGGGATCAACTATCGTTGTTCTGCTGTGTGGTGGCGACAAGTCA
TCACAGAGCCGGGATATCGCGCTGGCGAAACAAATGGCGAAGGAGATTTAG

Structures

Toxin

• AlphaFold DB: X7ZGG2

Antitoxin

• AlphaFold DB: X7ZF14