Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3640400..3641013 Replicon chromosome
Accession NZ_CP089218
Organism Mycobacterium kansasii strain FDAARGOS_1614

Toxin (Protein)


Gene name vapC Uniprot ID X7ZK47
Locus tag LTT71_RS15820 Protein ID WP_023365532.1
Coordinates 3640400..3640789 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LTT71_RS15825 Protein ID WP_036393214.1
Coordinates 3640786..3641013 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LTT71_RS15800 (LTT71_15800) 3635639..3636349 + 711 WP_023365512.1 hypothetical protein -
LTT71_RS15805 (LTT71_15805) 3637530..3637787 + 258 WP_099184175.1 hypothetical protein -
LTT71_RS15815 (LTT71_15815) 3639137..3639381 - 245 Protein_3140 tyrosine-type recombinase/integrase -
LTT71_RS15820 (LTT71_15820) 3640400..3640789 - 390 WP_023365532.1 type II toxin-antitoxin system VapC family toxin Toxin
LTT71_RS15825 (LTT71_15825) 3640786..3641013 - 228 WP_036393214.1 hypothetical protein Antitoxin
LTT71_RS15830 (LTT71_15830) 3641349..3643979 + 2631 WP_023365536.1 cation-transporting P-type ATPase -
LTT71_RS15835 (LTT71_15835) 3644024..3644251 - 228 WP_023365538.1 hypothetical protein -
LTT71_RS15840 (LTT71_15840) 3644274..3644654 - 381 WP_042313314.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 3629424..3660359 30935


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13970.16 Da        Isoelectric Point: 7.0619

>T227834 WP_023365532.1 NZ_CP089218:c3640789-3640400 [Mycobacterium kansasii]
VIVLDASAAVELVLATPPGAAVARRLRDETVHAPAHIDVEVIGAIRRAVVRRLISDHEGVVAVADFLSLQIRRWPIKPFA
QRAYQLRTTHIVADAVYVALAEGFGVRLITCDGRLAQSHGHDAEIELVA

Download         Length: 390 bp

>T227834 NZ_CP123048:37407-37556 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8173.38 Da        Isoelectric Point: 4.7513

>AT227834 WP_036393214.1 NZ_CP089218:c3641013-3640786 [Mycobacterium kansasii]
MSTMVQIRNVPDELVHELKARAAAQRMSLSDFLLARLAEFAQEPALDEVLGRLAALPRRDLGASAAELVGEARSE

Download         Length: 228 bp

>AT227834 NZ_CP123048:c37362-37303 [Escherichia coli]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X7ZK47

Antitoxin

Source ID Structure

References