Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1609765..1610440 Replicon chromosome
Accession NZ_CP089218
Organism Mycobacterium kansasii strain FDAARGOS_1614

Toxin (Protein)


Gene name vapC Uniprot ID X7ZNR6
Locus tag LTT71_RS06950 Protein ID WP_023372362.1
Coordinates 1609765..1610196 (-) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID X7ZS36
Locus tag LTT71_RS06955 Protein ID WP_036391998.1
Coordinates 1610183..1610440 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LTT71_RS06920 (LTT71_06920) 1605137..1605694 + 558 WP_023372356.1 ribosome recycling factor -
LTT71_RS06925 (LTT71_06925) 1605726..1606622 + 897 WP_023372357.1 phosphatidate cytidylyltransferase -
LTT71_RS06930 (LTT71_06930) 1606664..1607758 + 1095 WP_023372358.1 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN -
LTT71_RS06935 (LTT71_06935) 1607999..1608520 + 522 WP_023372359.1 protein disulfide oxidoreductase -
LTT71_RS06940 (LTT71_06940) 1608525..1609391 + 867 WP_023372360.1 cytochrome c biogenesis CcdA family protein -
LTT71_RS06945 (LTT71_06945) 1609384..1609638 - 255 WP_023372361.1 DUF2631 domain-containing protein -
LTT71_RS06950 (LTT71_06950) 1609765..1610196 - 432 WP_023372362.1 type II toxin-antitoxin system VapC family toxin Toxin
LTT71_RS06955 (LTT71_06955) 1610183..1610440 - 258 WP_036391998.1 ribbon-helix-helix domain-containing protein Antitoxin
LTT71_RS06960 (LTT71_06960) 1610528..1611733 + 1206 WP_036392002.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
LTT71_RS06965 (LTT71_06965) 1611753..1612967 + 1215 WP_023372365.1 M50 family metallopeptidase -
LTT71_RS06970 (LTT71_06970) 1612991..1614166 + 1176 WP_023372366.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
LTT71_RS06975 (LTT71_06975) 1614219..1615076 + 858 WP_023372367.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-35)


Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 16024.11 Da        Isoelectric Point: 6.3292

>T227832 WP_023372362.1 NZ_CP089218:c1610196-1609765 [Mycobacterium kansasii]
MHCVDVNVLVNAHRADLREHPNYRDVLERLANGDEPLGLPDSVLAGFVRVVTNRRIFVEPTSQPDAWQAVDALLAAPAAI
RLKPGERHWTLFRQLAADIDASGNDIADAYLAAYALENNATWVSADRGFARFGRLRWRHPLDM

Download         Length: 432 bp

>T227832 NZ_CP123047:93555-93704 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 8917.06 Da        Isoelectric Point: 7.9812

>AT227832 WP_036391998.1 NZ_CP089218:c1610440-1610183 [Mycobacterium kansasii]
VRTTIRIDDELYREVKARAARSGRTVAAVLEDAVRCGLNPPGQSAAGRYRVQPIGSGGLRPGVDLSSNAAVAEAMDEGVP
VDALR

Download         Length: 258 bp

>AT227832 NZ_CP123047:c93511-93450 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X7ZNR6

Antitoxin

Source ID Structure
AlphaFold DB X7ZS36

References