Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 3457535..3458220 Replicon chromosome
Accession NZ_CP089216
Organism Mycobacterium kansasii strain FDAARGOS_1615

Toxin (Protein)


Gene name vapC Uniprot ID X7ZUB0
Locus tag LTS70_RS15420 Protein ID WP_023373049.1
Coordinates 3457810..3458220 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LTS70_RS15415 Protein ID WP_036392171.1
Coordinates 3457535..3457813 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LTS70_RS15395 (LTS70_15395) 3454478..3454990 + 513 WP_036391447.1 Holliday junction resolvase RuvX -
LTS70_RS15400 (LTS70_15400) 3454983..3456230 + 1248 WP_023373040.1 endolytic transglycosylase MltG -
LTS70_RS15405 (LTS70_15405) 3456208..3457032 + 825 WP_023373043.1 shikimate dehydrogenase -
LTS70_RS15410 (LTS70_15410) 3457044..3457472 + 429 WP_023373045.1 A24 family peptidase -
LTS70_RS15415 (LTS70_15415) 3457535..3457813 + 279 WP_036392171.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LTS70_RS15420 (LTS70_15420) 3457810..3458220 + 411 WP_023373049.1 type II toxin-antitoxin system VapC family toxin Toxin
LTS70_RS15425 (LTS70_15425) 3458349..3459554 + 1206 WP_023373051.1 chorismate synthase -
LTS70_RS15430 (LTS70_15430) 3459571..3460107 + 537 WP_023373053.1 shikimate kinase -
LTS70_RS15435 (LTS70_15435) 3460104..3461192 + 1089 WP_023373055.1 3-dehydroquinate synthase -
LTS70_RS15440 (LTS70_15440) 3461189..3461629 + 441 WP_023373057.1 type II 3-dehydroquinate dehydratase -
LTS70_RS15445 (LTS70_15445) 3461626..3462378 - 753 WP_036448656.1 B-4DMT family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-118)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-48)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14705.90 Da        Isoelectric Point: 4.8944

>T227823 WP_023373049.1 NZ_CP089216:3457810-3458220 [Mycobacterium kansasii]
VIYLDTSALTKLLIAEPETDELRNWLTVHTDQGEFAATSALSRVELMRVVARQGESGQAERARYLLDGLDILPLTAPVIN
LAETIGPATLRTLDAIHLAAATQIKRELTAFVTYDHRLLAGCLEVGLVTASPGAVR

Download         Length: 411 bp

>T227823 NZ_CP123046:3781023-3781301 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10114.45 Da        Isoelectric Point: 4.8604

>AT227823 WP_036392171.1 NZ_CP089216:3457535-3457813 [Mycobacterium kansasii]
VEAIGVRELRQHASRYLARVEAGEELGITNNGRLVARLVPVQAAERSREALIESGTLIPAPCPQNLLDVTATPAPDRKRT
LSDVLDEMRDEQ

Download         Length: 279 bp

>AT227823 NZ_CP123046:3780760-3781020 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X7ZUB0

Antitoxin

Source ID Structure

References