Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/PIN(toxin) |
| Location | 3069306..3069981 | Replicon | chromosome |
| Accession | NZ_CP089216 | ||
| Organism | Mycobacterium kansasii strain FDAARGOS_1615 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | X7ZNR6 |
| Locus tag | LTS70_RS13555 | Protein ID | WP_023372362.1 |
| Coordinates | 3069306..3069737 (-) | Length | 144 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | X7ZS36 |
| Locus tag | LTS70_RS13560 | Protein ID | WP_036391998.1 |
| Coordinates | 3069724..3069981 (-) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LTS70_RS13525 (LTS70_13525) | 3064678..3065235 | + | 558 | WP_023372356.1 | ribosome recycling factor | - |
| LTS70_RS13530 (LTS70_13530) | 3065267..3066163 | + | 897 | WP_023372357.1 | phosphatidate cytidylyltransferase | - |
| LTS70_RS13535 (LTS70_13535) | 3066205..3067299 | + | 1095 | WP_023372358.1 | 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN | - |
| LTS70_RS13540 (LTS70_13540) | 3067540..3068061 | + | 522 | WP_023372359.1 | protein disulfide oxidoreductase | - |
| LTS70_RS13545 (LTS70_13545) | 3068066..3068932 | + | 867 | WP_023372360.1 | cytochrome c biogenesis CcdA family protein | - |
| LTS70_RS13550 (LTS70_13550) | 3068925..3069179 | - | 255 | WP_023372361.1 | DUF2631 domain-containing protein | - |
| LTS70_RS13555 (LTS70_13555) | 3069306..3069737 | - | 432 | WP_023372362.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| LTS70_RS13560 (LTS70_13560) | 3069724..3069981 | - | 258 | WP_036391998.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
| LTS70_RS13565 (LTS70_13565) | 3070069..3071274 | + | 1206 | WP_036392002.1 | 1-deoxy-D-xylulose-5-phosphate reductoisomerase | - |
| LTS70_RS13570 (LTS70_13570) | 3071294..3072508 | + | 1215 | WP_023372365.1 | M50 family metallopeptidase | - |
| LTS70_RS13575 (LTS70_13575) | 3072532..3073707 | + | 1176 | WP_023372366.1 | flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase | - |
| LTS70_RS13580 (LTS70_13580) | 3073760..3074617 | + | 858 | WP_023372367.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 144 a.a. Molecular weight: 16024.11 Da Isoelectric Point: 6.3292
>T227822 WP_023372362.1 NZ_CP089216:c3069737-3069306 [Mycobacterium kansasii]
MHCVDVNVLVNAHRADLREHPNYRDVLERLANGDEPLGLPDSVLAGFVRVVTNRRIFVEPTSQPDAWQAVDALLAAPAAI
RLKPGERHWTLFRQLAADIDASGNDIADAYLAAYALENNATWVSADRGFARFGRLRWRHPLDM
MHCVDVNVLVNAHRADLREHPNYRDVLERLANGDEPLGLPDSVLAGFVRVVTNRRIFVEPTSQPDAWQAVDALLAAPAAI
RLKPGERHWTLFRQLAADIDASGNDIADAYLAAYALENNATWVSADRGFARFGRLRWRHPLDM
Download Length: 432 bp
>T227822 NZ_CP123046:3555820-3556362 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG
Antitoxin
Download Length: 86 a.a. Molecular weight: 8917.06 Da Isoelectric Point: 7.9812
>AT227822 WP_036391998.1 NZ_CP089216:c3069981-3069724 [Mycobacterium kansasii]
VRTTIRIDDELYREVKARAARSGRTVAAVLEDAVRCGLNPPGQSAAGRYRVQPIGSGGLRPGVDLSSNAAVAEAMDEGVP
VDALR
VRTTIRIDDELYREVKARAARSGRTVAAVLEDAVRCGLNPPGQSAAGRYRVQPIGSGGLRPGVDLSSNAAVAEAMDEGVP
VDALR
Download Length: 258 bp
>AT227822 NZ_CP123046:3555525-3555836 [Escherichia coli]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
TGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
TGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|