Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1864438..1865063 Replicon chromosome
Accession NZ_CP089216
Organism Mycobacterium kansasii strain FDAARGOS_1615

Toxin (Protein)


Gene name vapC Uniprot ID X7YX14
Locus tag LTS70_RS08395 Protein ID WP_023370764.1
Coordinates 1864662..1865063 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID X7YXT3
Locus tag LTS70_RS08390 Protein ID WP_023370762.1
Coordinates 1864438..1864665 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LTS70_RS08375 (LTS70_08375) 1859733..1860899 + 1167 WP_023370756.1 LarC family nickel insertion protein -
LTS70_RS08380 (LTS70_08380) 1860906..1862078 - 1173 WP_023370758.1 MFS transporter -
LTS70_RS08385 (LTS70_08385) 1862374..1864317 - 1944 Protein_1654 SEC-C domain-containing protein -
LTS70_RS08390 (LTS70_08390) 1864438..1864665 + 228 WP_023370762.1 hypothetical protein Antitoxin
LTS70_RS08395 (LTS70_08395) 1864662..1865063 + 402 WP_023370764.1 PIN domain-containing protein Toxin
LTS70_RS08400 (LTS70_08400) 1865148..1866104 + 957 WP_023370766.1 class I SAM-dependent methyltransferase -
LTS70_RS08405 (LTS70_08405) 1866284..1867408 + 1125 WP_230589192.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14053.99 Da        Isoelectric Point: 6.3696

>T227820 WP_023370764.1 NZ_CP089216:1864662-1865063 [Mycobacterium kansasii]
VIALLDSNVLIALVVAEHVHHDVAAAWLSARDNGFATCPITQGSLVRFLMRTGQPAAVAREVVGAVETAKRHEFWPDSVS
FADVEIGGVVGHRQVTDAYLAQLARSRNGQLATLDSGLAHLHSDVAVLIPTAG

Download         Length: 402 bp

>T227820 NZ_CP123046:2717325-2717432 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8012.00 Da        Isoelectric Point: 4.7377

>AT227820 WP_023370762.1 NZ_CP089216:1864438-1864665 [Mycobacterium kansasii]
VRTTIDLPDDLHKQALAIARDTRRTLSETVADLMRRGLGAGGAAAISTDPRTGLPLVNVGKVVTSEDVRSLEDEE

Download         Length: 228 bp

>AT227820 NZ_CP123046:c2717269-2717213 [Escherichia coli]
TCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X7YX14

Antitoxin

Source ID Structure
AlphaFold DB X7YXT3

References