227815

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Fic(toxin)
Location 2657861..2658444 Replicon chromosome
Accession NZ_CP089215
Organism Mycolicibacterium smegmatis strain FDAARGOS_1618

Toxin (Protein)


Gene name doc Uniprot ID A0A2U9PKR4
Locus tag LTT02_RS12900 Protein ID WP_003892660.1
Coordinates 2657861..2658250 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A2U9PKT9
Locus tag LTT02_RS12905 Protein ID WP_011727559.1
Coordinates 2658247..2658444 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LTT02_RS12890 (LTT02_12890) 2655779..2656357 - 579 WP_038557632.1 DUF4194 domain-containing protein -
LTT02_RS12895 (LTT02_12895) 2656354..2657784 - 1431 WP_058125484.1 DUF3375 domain-containing protein -
LTT02_RS12900 (LTT02_12900) 2657861..2658250 - 390 WP_003892660.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
LTT02_RS12905 (LTT02_12905) 2658247..2658444 - 198 WP_011727559.1 type II toxin-antitoxin system antitoxin Phd Antitoxin
LTT02_RS12910 (LTT02_12910) 2658592..2658888 - 297 WP_003892658.1 nucleoside triphosphate pyrophosphohydrolase -
LTT02_RS12915 (LTT02_12915) 2658956..2660035 + 1080 WP_058125483.1 HNH endonuclease domain-containing protein -
LTT02_RS12920 (LTT02_12920) 2660270..2661343 + 1074 WP_223495413.1 SMP-30/gluconolactonase/LRE family protein -
LTT02_RS12925 (LTT02_12925) 2661452..2662531 + 1080 WP_058125481.1 HNH endonuclease domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(18-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13868.49 Da        Isoelectric Point: 4.2481

>T227815 WP_003892660.1 NZ_CP089215:c2658250-2657861 [Mycolicibacterium smegmatis]
VTEYLDREDVLTAGSIAFGGELKVRDYGLLDAAVARPQATVYGVDAYPRLWDKAAALLQSLARNHALVDGNKRTAWAAAW
TFLHINGVQLAADFDVDRAEDLMNEVATRDCDLDSIAAELAGFAAAQTG

Download         Length: 390 bp

>T227815 NZ_CP123046:1339234-1339632 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7276.30 Da        Isoelectric Point: 8.9353

>AT227815 WP_011727559.1 NZ_CP089215:c2658444-2658247 [Mycolicibacterium smegmatis]
MPSLNIDFDEAEMEQIRAAARADDLSLKKFAHAAVMERASAHKRRVAEAARLVAERSAELNRRLA

Download         Length: 198 bp

>AT227815 NZ_CP123046:1339007-1339234 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U9PKR4

Antitoxin

Source ID Structure
AlphaFold DB A0A2U9PKT9

References