Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Fic(toxin)
Location 4402213..4402784 Replicon chromosome
Accession NZ_CP089214
Organism Nocardia asteroides strain FDAARGOS_1620

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag LTT61_RS20950 Protein ID WP_233015770.1
Coordinates 4402407..4402784 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag LTT61_RS20945 Protein ID WP_233015769.1
Coordinates 4402213..4402410 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LTT61_RS20925 (LTT61_20925) 4398182..4398601 + 420 WP_233015765.1 glyoxalase/bleomycin resistance/extradiol dioxygenase family protein -
LTT61_RS20930 (LTT61_20930) 4398668..4399447 - 780 WP_233015766.1 crotonase/enoyl-CoA hydratase family protein -
LTT61_RS20935 (LTT61_20935) 4399509..4401152 + 1644 WP_233015767.1 acyl-CoA synthetase -
LTT61_RS20940 (LTT61_20940) 4401218..4402072 + 855 WP_233015768.1 thioesterase family protein -
LTT61_RS20945 (LTT61_20945) 4402213..4402410 + 198 WP_233015769.1 DUF6290 family protein Antitoxin
LTT61_RS20950 (LTT61_20950) 4402407..4402784 + 378 WP_233015770.1 Fic family protein Toxin
LTT61_RS20955 (LTT61_20955) 4402781..4403884 - 1104 WP_233015771.1 acyl-CoA dehydrogenase family protein -
LTT61_RS20960 (LTT61_20960) 4403927..4405120 - 1194 WP_233015772.1 acyl-CoA dehydrogenase family protein -
LTT61_RS20965 (LTT61_20965) 4405286..4405474 + 189 WP_233015773.1 ferredoxin -
LTT61_RS20970 (LTT61_20970) 4405518..4406423 + 906 WP_233015774.1 3-oxoacyl-ACP reductase -
LTT61_RS20975 (LTT61_20975) 4406676..4407440 + 765 WP_233015775.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(13-118)

Antitoxin

Protein of unknown function DUF6290

(1-48)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13713.64 Da        Isoelectric Point: 4.8134

>T227811 WP_233015770.1 NZ_CP089214:4402407-4402784 [Nocardia asteroides]
VIEYLTLPELLGLAQRLGTPEVRDYGLLDSALARPRTSVFGQDAYADLWHKAAALMESVARNHGLVDGNKRLAWYATWVF
LHLNGYPLDPGFDVDRAERFVLAVCQGEFGVPAIAAELPSFAATP

Download         Length: 378 bp

>T227811 NZ_CP123046:283265-283792 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATAAAAAAGCCCATACGTTTTATCAATCGCTGGGCTTTATCCCGTTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATCGAACTGCTTTTCACACAGAGCGATTAA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7345.21 Da        Isoelectric Point: 5.0351

>AT227811 WP_233015769.1 NZ_CP089214:4402213-4402410 [Nocardia asteroides]
MAGLNIRFSDDELDALRQRAEAEGTSMQQFVRNAVITAISERARIFNEAADHVLRASEELNRRLA

Download         Length: 198 bp

>AT227811 NZ_CP123046:282992-283258 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCTGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References