Detailed information of TA system TA022781

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 272373..272949
• Replicon: chromosome
• Accession: NC_010547
• Organism: Cyanothece sp. ATCC 51142

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: B1X2M3
• Locus tag: CCE_RS23760
• Protein ID: WP_009546203.1
• Coordinates: 272680..272949 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: B1X2M2
• Locus tag: CCE_RS23755
• Protein ID: WP_009546204.1
• Coordinates: 272373..272690 (-)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCE_RS23725	268021..268674	+	654	WP_009546210.1	HAD-IA family hydrolase	-
CCE_RS23730	268705..269463	+	759	WP_009546209.1	AAA family ATPase	-
CCE_RS23735	269486..270460	+	975	WP_009546208.1	ParB/RepB/Spo0J family partition protein	-
CCE_RS23740	270541..270768	-	228	WP_009546207.1	exodeoxyribonuclease VII small subunit	-
CCE_RS23745	270771..271922	-	1152	WP_024750379.1	exodeoxyribonuclease VII large subunit	-
CCE_RS23750	271919..272365	-	447	WP_009546205.1	GNAT family N-acetyltransferase	-
CCE_RS23755	272373..272690	-	318	WP_009546204.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
CCE_RS23760	272680..272949	-	270	WP_009546203.1	type II toxin-antitoxin system HicA family toxin	Toxin
CCE_RS23765	273000..274220	-	1221	WP_009546202.1	tyrosine-type recombinase/integrase	-
CCE_RS23770	274376..275215	-	840	WP_009546201.1	hypothetical protein	-
CCE_RS23775	275504..275704	+	201	WP_009546200.1	helix-turn-helix domain-containing protein	-
CCE_RS23780	275748..277664	-	1917	WP_009546199.1	CHASE2 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (25-83)

Antitoxin

• Uncharacterised protein family HicB (51-101)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 9867.38 Da
• Isoelectric Point: 10.8780

>T22781 WP_009546203.1 NC_010547:c272949-272680 [Crocosphaera subtropica ATCC 51142]
MALNKKQQKTLSKLFEQPVRSDISWKDIESLLLALGAEISEGRGSRVRVALNGVRAVFHRPHPQPQTDKGAVGSMRRFLT
EAGVKADEI

Nucleotide

• Length: 270 bp

>T22781 NC_010547:c272949-272680 [Crocosphaera subtropica ATCC 51142]
ATGGCACTAAACAAAAAACAACAAAAAACGCTCTCTAAGCTTTTTGAGCAACCAGTGCGCTCAGACATATCCTGGAAAGA
TATTGAGTCCTTACTATTAGCGTTGGGAGCGGAAATATCCGAAGGAAGAGGCTCGAGAGTGAGGGTAGCTCTCAATGGAG
TTAGAGCAGTTTTTCACCGTCCCCACCCCCAACCTCAAACGGATAAGGGGGCAGTGGGATCAATGAGACGATTTTTAACT
GAAGCAGGAGTAAAAGCTGATGAAATATAA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11943.43 Da
• Isoelectric Point: 4.7443

>AT22781 WP_009546204.1 NC_010547:c272690-272373 [Crocosphaera subtropica ATCC 51142]
MKYKGYEAVVSVDDEQGIFHGEVINIRDVITFQGQSFSELKQAFIESVEDYLEFCAQRGEEPDKPFSGRFVVRIDPELHK
QISIKAKQEGKSLNTWVSEKLSSGV

Nucleotide

• Length: 318 bp

>AT22781 NC_010547:c272690-272373 [Crocosphaera subtropica ATCC 51142]
ATGAAATATAAAGGATATGAAGCAGTGGTTTCGGTTGATGATGAACAAGGAATCTTTCATGGTGAAGTAATTAATATTAG
GGATGTAATAACGTTCCAAGGTCAAAGCTTTTCTGAATTAAAACAAGCTTTTATTGAATCAGTAGAAGATTATTTAGAGT
TTTGCGCTCAACGAGGAGAAGAACCAGATAAACCGTTTTCAGGTCGTTTTGTAGTGAGAATTGACCCTGAGTTACATAAA
CAAATTTCTATTAAAGCTAAACAAGAAGGAAAAAGCTTGAACACATGGGTGAGTGAGAAATTATCTTCTGGAGTTTAA

Structures

Toxin

• AlphaFold DB: B1X2M3

Antitoxin

• AlphaFold DB: B1X2M2