Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 5086231..5087252 Replicon chromosome
Accession NZ_CP089212
Organism Nocardia asteroides strain FDAARGOS_1621

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag LTT85_RS23845 Protein ID WP_232996865.1
Coordinates 5086231..5086794 (-) Length 188 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag LTT85_RS23850 Protein ID WP_232996867.1
Coordinates 5086794..5087252 (-) Length 153 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LTT85_RS23815 (LTT85_23815) 5081262..5081792 + 531 WP_110036976.1 PH domain-containing protein -
LTT85_RS23820 (LTT85_23820) 5081822..5082520 + 699 WP_110036975.1 response regulator transcription factor -
LTT85_RS23825 (LTT85_23825) 5082520..5083827 + 1308 WP_232996862.1 HAMP domain-containing sensor histidine kinase -
LTT85_RS23830 (LTT85_23830) 5083829..5084377 - 549 WP_110036973.1 GtrA family protein -
LTT85_RS23835 (LTT85_23835) 5084465..5085640 + 1176 WP_233001679.1 5-(carboxyamino)imidazole ribonucleotide synthase -
LTT85_RS23840 (LTT85_23840) 5085669..5086172 + 504 WP_232996863.1 5-(carboxyamino)imidazole ribonucleotide mutase -
LTT85_RS23845 (LTT85_23845) 5086231..5086794 - 564 WP_232996865.1 PIN domain-containing protein Toxin
LTT85_RS23850 (LTT85_23850) 5086794..5087252 - 459 WP_232996867.1 helix-turn-helix domain-containing protein Antitoxin
LTT85_RS23855 (LTT85_23855) 5087404..5088063 + 660 WP_232996869.1 TetR family transcriptional regulator -
LTT85_RS23860 (LTT85_23860) 5088226..5089383 + 1158 WP_110036969.1 acyl-CoA dehydrogenase -
LTT85_RS23865 (LTT85_23865) 5089920..5090591 + 672 WP_232996870.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-112)

Antitoxin

Helix-turn-helix domain, group 17

(84-131)


Sequences

Toxin        


Download         Length: 188 a.a.        Molecular weight: 20926.93 Da        Isoelectric Point: 4.4654

>T227809 WP_232996865.1 NZ_CP089212:c5086794-5086231 [Nocardia asteroides]
MAFIVVYDANILYGNAVRDLFIRLARAKVVQAKWTDRILDEALGNLSTKRPDIPADKIGRLRQMIIAAVPDCRIEGYEPL
VESLKLPDADDRHVLAAAIRAGAQVIVTSNLKDFPEDYLTPWNVTAKSPDDFLLDLIDLDDRVVWACVQEIAYSRRNPPE
TTEDVLDELERAGLVEAVASLREGRTP

Download         Length: 564 bp

>T227809 NZ_CP123046:188529-188636 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 153 a.a.        Molecular weight: 16583.87 Da        Isoelectric Point: 6.1044

>AT227809 WP_232996867.1 NZ_CP089212:c5087252-5086794 [Nocardia asteroides]
MSGIQSAKRTEPGAIDAAVADRAMRRIKDYLMRHPDEEIIPVTGEIGSDEALALPREAVSLLAFILAQAAEGRGVSVVPS
HAEMTTQQAADMLNVSRPYLVGLLENGEIPHRLVGRHRRIRFDDLKAYAQRSEATSRAAADELTRLGQELGL

Download         Length: 459 bp

>AT227809 NZ_CP123046:c188472-188417 [Escherichia coli]
TCAAGATTAGCCCCCGTTATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References