Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relE-yefM/YoeB-RelB |
Location | 4230344..4230863 | Replicon | chromosome |
Accession | NZ_CP089212 | ||
Organism | Nocardia asteroides strain FDAARGOS_1621 |
Toxin (Protein)
Gene name | relE | Uniprot ID | - |
Locus tag | LTT85_RS19895 | Protein ID | WP_232996213.1 |
Coordinates | 4230344..4230613 (-) | Length | 90 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | - |
Locus tag | LTT85_RS19900 | Protein ID | WP_232996214.1 |
Coordinates | 4230606..4230863 (-) | Length | 86 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LTT85_RS19885 (LTT85_19885) | 4228069..4228503 | - | 435 | WP_232996211.1 | MarR family transcriptional regulator | - |
LTT85_RS19890 (LTT85_19890) | 4228811..4230127 | + | 1317 | WP_232996212.1 | aminotransferase class V-fold PLP-dependent enzyme | - |
LTT85_RS19895 (LTT85_19895) | 4230344..4230613 | - | 270 | WP_232996213.1 | Txe/YoeB family addiction module toxin | Toxin |
LTT85_RS19900 (LTT85_19900) | 4230606..4230863 | - | 258 | WP_232996214.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
LTT85_RS19905 (LTT85_19905) | 4230911..4231378 | - | 468 | WP_233001646.1 | flavin reductase family protein | - |
LTT85_RS19910 (LTT85_19910) | 4231759..4232235 | - | 477 | WP_232996215.1 | YbaK/EbsC family protein | - |
LTT85_RS19915 (LTT85_19915) | 4232342..4233163 | + | 822 | WP_110041418.1 | crotonase/enoyl-CoA hydratase family protein | - |
LTT85_RS19920 (LTT85_19920) | 4233255..4233749 | + | 495 | WP_232996216.1 | MarR family transcriptional regulator | - |
LTT85_RS19925 (LTT85_19925) | 4233746..4235425 | + | 1680 | WP_232996217.1 | MDR family MFS transporter | - |
LTT85_RS19930 (LTT85_19930) | 4235549..4235776 | + | 228 | WP_110041415.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10101.56 Da Isoelectric Point: 8.9299
>T227808 WP_232996213.1 NZ_CP089212:c4230613-4230344 [Nocardia asteroides]
MPERKLVFSAYGWETYTSWLTRDRTVLKAANKVIAAALADPFTGIGKPEPLKHHLSGSWSRRINREHRMIYCVTDSEIVV
IAVGGHYDD
MPERKLVFSAYGWETYTSWLTRDRTVLKAANKVIAAALADPFTGIGKPEPLKHHLSGSWSRRINREHRMIYCVTDSEIVV
IAVGGHYDD
Download Length: 270 bp
>T227808 NZ_CP123044:73380-73685 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGATGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGATGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9331.40 Da Isoelectric Point: 4.4193
>AT227808 WP_232996214.1 NZ_CP089212:c4230863-4230606 [Nocardia asteroides]
MTALPISTARQNLFKLVQQVNDDHDTVTVVTKSGENAVLVAESDWNAIQETLYVLATHGGVRLLESAREAREGKFEAHDL
IDPDA
MTALPISTARQNLFKLVQQVNDDHDTVTVVTKSGENAVLVAESDWNAIQETLYVLATHGGVRLLESAREAREGKFEAHDL
IDPDA
Download Length: 258 bp
>AT227808 NZ_CP123044:73160-73378 [Klebsiella pneumoniae]
ATGAAGCAGCGCATCACTGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTTCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA
ATGAAGCAGCGCATCACTGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTTCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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