Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-RelB
Location 4230344..4230863 Replicon chromosome
Accession NZ_CP089212
Organism Nocardia asteroides strain FDAARGOS_1621

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LTT85_RS19895 Protein ID WP_232996213.1
Coordinates 4230344..4230613 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag LTT85_RS19900 Protein ID WP_232996214.1
Coordinates 4230606..4230863 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LTT85_RS19885 (LTT85_19885) 4228069..4228503 - 435 WP_232996211.1 MarR family transcriptional regulator -
LTT85_RS19890 (LTT85_19890) 4228811..4230127 + 1317 WP_232996212.1 aminotransferase class V-fold PLP-dependent enzyme -
LTT85_RS19895 (LTT85_19895) 4230344..4230613 - 270 WP_232996213.1 Txe/YoeB family addiction module toxin Toxin
LTT85_RS19900 (LTT85_19900) 4230606..4230863 - 258 WP_232996214.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LTT85_RS19905 (LTT85_19905) 4230911..4231378 - 468 WP_233001646.1 flavin reductase family protein -
LTT85_RS19910 (LTT85_19910) 4231759..4232235 - 477 WP_232996215.1 YbaK/EbsC family protein -
LTT85_RS19915 (LTT85_19915) 4232342..4233163 + 822 WP_110041418.1 crotonase/enoyl-CoA hydratase family protein -
LTT85_RS19920 (LTT85_19920) 4233255..4233749 + 495 WP_232996216.1 MarR family transcriptional regulator -
LTT85_RS19925 (LTT85_19925) 4233746..4235425 + 1680 WP_232996217.1 MDR family MFS transporter -
LTT85_RS19930 (LTT85_19930) 4235549..4235776 + 228 WP_110041415.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-66)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10101.56 Da        Isoelectric Point: 8.9299

>T227808 WP_232996213.1 NZ_CP089212:c4230613-4230344 [Nocardia asteroides]
MPERKLVFSAYGWETYTSWLTRDRTVLKAANKVIAAALADPFTGIGKPEPLKHHLSGSWSRRINREHRMIYCVTDSEIVV
IAVGGHYDD

Download         Length: 270 bp

>T227808 NZ_CP123044:73380-73685 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGATGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9331.40 Da        Isoelectric Point: 4.4193

>AT227808 WP_232996214.1 NZ_CP089212:c4230863-4230606 [Nocardia asteroides]
MTALPISTARQNLFKLVQQVNDDHDTVTVVTKSGENAVLVAESDWNAIQETLYVLATHGGVRLLESAREAREGKFEAHDL
IDPDA

Download         Length: 258 bp

>AT227808 NZ_CP123044:73160-73378 [Klebsiella pneumoniae]
ATGAAGCAGCGCATCACTGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTTCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References