Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3463989..3464599 Replicon chromosome
Accession NZ_CP089212
Organism Nocardia asteroides strain FDAARGOS_1621

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LTT85_RS16380 Protein ID WP_233001229.1
Coordinates 3464201..3464599 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LTT85_RS16375 Protein ID WP_233001227.1
Coordinates 3463989..3464189 (+) Length 67 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LTT85_RS16365 (LTT85_16365) 3459433..3460176 - 744 WP_233001223.1 hypothetical protein -
LTT85_RS16370 (LTT85_16370) 3460634..3463870 + 3237 WP_233001225.1 (Fe-S)-binding protein -
LTT85_RS16375 (LTT85_16375) 3463989..3464189 + 201 WP_233001227.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LTT85_RS16380 (LTT85_16380) 3464201..3464599 + 399 WP_233001229.1 PIN domain nuclease Toxin
LTT85_RS16385 (LTT85_16385) 3464613..3465137 - 525 WP_233001231.1 YdcF family protein -
LTT85_RS16390 (LTT85_16390) 3465342..3466664 + 1323 WP_233001233.1 UDP-glucose/GDP-mannose dehydrogenase family protein -
LTT85_RS16395 (LTT85_16395) 3466754..3468112 + 1359 WP_233001235.1 Hsp70 family protein -
LTT85_RS16400 (LTT85_16400) 3468114..3469388 - 1275 WP_233001237.1 YibE/F family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-119)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-41)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14054.01 Da        Isoelectric Point: 5.7714

>T227807 WP_233001229.1 NZ_CP089212:3464201-3464599 [Nocardia asteroides]
MLADKSAIEWVLRDPTAAADFHAVTSTPGALVAACHLTALEIGYSARSLADYTAKIGHQKALVWLPATEEAMDRALAVQG
LLAERGAHRLPIPDLIIAATAEVHGATVMHVDSDYETIAEVTGQPHHRLPTT

Download         Length: 399 bp

>T227807 NZ_CP123043:c5356341-5355958 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 67 a.a.        Molecular weight: 7246.26 Da        Isoelectric Point: 6.2748

>AT227807 WP_233001227.1 NZ_CP089212:3463989-3464189 [Nocardia asteroides]
MSRTLIDIDDDALALAAEELGTKTKVATVNAALREVANRRAVAKMLQQFRESNTDLSPEGMKGAWR

Download         Length: 201 bp

>AT227807 NZ_CP123043:c5356583-5356341 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References