Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2992684..2993309 Replicon chromosome
Accession NZ_CP089212
Organism Nocardia asteroides strain FDAARGOS_1621

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LTT85_RS14065 Protein ID WP_233000839.1
Coordinates 2992684..2993103 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LTT85_RS14070 Protein ID WP_233000840.1
Coordinates 2993100..2993309 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LTT85_RS14035 (LTT85_14035) 2987957..2988382 - 426 WP_233000833.1 PPOX class F420-dependent oxidoreductase -
LTT85_RS14040 (LTT85_14040) 2988437..2989054 - 618 WP_233000834.1 response regulator transcription factor -
LTT85_RS14045 (LTT85_14045) 2989051..2990310 - 1260 WP_233000835.1 sensor histidine kinase -
LTT85_RS14050 (LTT85_14050) 2990440..2991492 + 1053 WP_233000836.1 ABC transporter permease -
LTT85_RS14055 (LTT85_14055) 2991504..2992247 + 744 WP_233000837.1 ABC transporter ATP-binding protein -
LTT85_RS14060 (LTT85_14060) 2992293..2992682 + 390 WP_233000838.1 NYN domain-containing protein -
LTT85_RS14065 (LTT85_14065) 2992684..2993103 - 420 WP_233000839.1 PIN domain-containing protein Toxin
LTT85_RS14070 (LTT85_14070) 2993100..2993309 - 210 WP_233000840.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LTT85_RS14075 (LTT85_14075) 2993407..2994105 - 699 WP_233000841.1 TetR/AcrR family transcriptional regulator -
LTT85_RS14080 (LTT85_14080) 2994200..2995807 + 1608 WP_233000842.1 carboxyl transferase domain-containing protein -
LTT85_RS14085 (LTT85_14085) 2995813..2997864 + 2052 WP_233000843.1 acetyl/propionyl/methylcrotonyl-CoA carboxylase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(6-35)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15156.26 Da        Isoelectric Point: 5.6319

>T227806 WP_233000839.1 NZ_CP089212:c2993103-2992684 [Nocardia asteroides]
VISYLIDTSAVARLLANPGVRRAWQETVTAGVIAVCDAVELELLFTATSLADRRRKKELLDDLFGWVPTPDGVWTRAQQV
QLLLTEQGHHRSAGVADLVIAGTAEANRLTVLHYDRDFETVAKATGQPTQWIAPPGTVP

Download         Length: 420 bp

>T227806 NZ_CP123043:c5032894-5031977 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCAATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7710.82 Da        Isoelectric Point: 6.3135

>AT227806 WP_233000840.1 NZ_CP089212:c2993309-2993100 [Nocardia asteroides]
MSKLMIEVDDEALAEAQRLLGTTTKKDTVNAALAEVSRRLKRVKALNGLAEMAEQGDFDTLLDKSNYRR

Download         Length: 210 bp

>AT227806 NZ_CP123043:c5033658-5032900 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References