227801

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2427438..2427915 Replicon chromosome
Accession NZ_CP089165
Organism Staphylococcus aureus strain UNC_SaCF07

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag LTK18_RS12085 Protein ID WP_000052076.1
Coordinates 2427727..2427915 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag LTK18_RS12080 Protein ID WP_001059690.1
Coordinates 2427438..2427698 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LTK18_RS12045 (LTK18_12045) 2422831..2423547 - 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -
LTK18_RS12050 (LTK18_12050) 2423695..2424117 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
LTK18_RS12055 (LTK18_12055) 2424516..2425010 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
LTK18_RS12060 (LTK18_12060) 2425165..2425782 + 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
LTK18_RS12065 (LTK18_12065) 2425855..2426436 - 582 WP_001140693.1 histidine phosphatase family protein -
LTK18_RS12070 (LTK18_12070) 2426661..2426897 + 237 WP_000349581.1 hypothetical protein -
LTK18_RS12075 (LTK18_12075) 2426894..2427097 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
LTK18_RS12080 (LTK18_12080) 2427438..2427698 + 261 WP_001059690.1 hypothetical protein Antitoxin
LTK18_RS12085 (LTK18_12085) 2427727..2427915 + 189 WP_000052076.1 hypothetical protein Toxin
LTK18_RS12090 (LTK18_12090) 2428103..2428672 + 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
LTK18_RS12095 (LTK18_12095) 2428760..2429044 + 285 WP_001004399.1 hypothetical protein -
LTK18_RS12100 (LTK18_12100) 2429106..2429324 + 219 WP_000005886.1 hypothetical protein -
LTK18_RS12105 (LTK18_12105) 2429816..2430016 - 201 WP_001059082.1 cold-shock protein -
LTK18_RS12110 (LTK18_12110) 2430373..2431059 - 687 WP_000141557.1 thermonuclease family protein -
LTK18_RS12115 (LTK18_12115) 2431400..2431921 - 522 WP_000824482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T227801 WP_000052076.1 NZ_CP089165:2427727-2427915 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T227801 NZ_CP123043:1990359-1990461 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT227801 WP_001059690.1 NZ_CP089165:2427438-2427698 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT227801 NZ_CP123043:c1990468-1990323 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References