Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1393314..1394090 Replicon chromosome
Accession NZ_CP089165
Organism Staphylococcus aureus strain UNC_SaCF07

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag LTK18_RS07120 Protein ID WP_000031108.1
Coordinates 1393938..1394090 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag LTK18_RS07115 Protein ID WP_001251224.1
Coordinates 1393314..1393913 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LTK18_RS07095 (LTK18_07095) 1389230..1390687 + 1458 WP_000649908.1 ABC transporter permease subunit -
LTK18_RS07100 (LTK18_07100) 1390680..1391402 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
LTK18_RS07105 (LTK18_07105) 1391553..1392680 + 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
LTK18_RS07110 (LTK18_07110) 1392685..1393155 + 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
LTK18_RS07115 (LTK18_07115) 1393314..1393913 + 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
LTK18_RS07120 (LTK18_07120) 1393938..1394090 + 153 WP_000031108.1 SAS053 family protein Toxin
LTK18_RS07125 (LTK18_07125) 1394638..1395033 + 396 WP_000901023.1 hypothetical protein -
LTK18_RS07130 (LTK18_07130) 1395229..1396614 + 1386 WP_000116228.1 class II fumarate hydratase -
LTK18_RS07135 (LTK18_07135) 1397067..1397888 - 822 WP_000669376.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T227798 WP_000031108.1 NZ_CP089165:1393938-1394090 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T227798 NZ_CP123043:337793-338161 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCTGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT227798 WP_001251224.1 NZ_CP089165:1393314-1393913 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT227798 NZ_CP123043:337575-337796 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References