Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1176456..1176970 Replicon chromosome
Accession NZ_CP089165
Organism Staphylococcus aureus strain UNC_SaCF07

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag LTK18_RS05800 Protein ID WP_000581792.1
Coordinates 1176761..1176970 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag LTK18_RS05795 Protein ID WP_000138932.1
Coordinates 1176456..1176749 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LTK18_RS05775 (LTK18_05775) 1171619..1172260 + 642 WP_000483153.1 thiamine phosphate synthase -
LTK18_RS05780 (LTK18_05780) 1172346..1173218 + 873 WP_000725802.1 membrane protein insertase YidC -
LTK18_RS05785 (LTK18_05785) 1174131..1174778 - 648 WP_001187630.1 HD domain-containing protein -
LTK18_RS05790 (LTK18_05790) 1174806..1176290 - 1485 WP_000571549.1 cardiolipin synthase -
LTK18_RS05795 (LTK18_05795) 1176456..1176749 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
LTK18_RS05800 (LTK18_05800) 1176761..1176970 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
LTK18_RS05805 (LTK18_05805) 1177098..1177235 + 138 WP_000828354.1 Lmo0850 family protein -
LTK18_RS05810 (LTK18_05810) 1177499..1178701 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
LTK18_RS05815 (LTK18_05815) 1179019..1180089 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
LTK18_RS05820 (LTK18_05820) 1180104..1181462 + 1359 WP_031870280.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T227796 WP_000581792.1 NZ_CP089165:1176761-1176970 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T227796 NZ_CP123040:c5300683-5300300 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT227796 WP_000138932.1 NZ_CP089165:1176456-1176749 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT227796 NZ_CP123040:c5300925-5300683 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References