227788

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 802730..803253 Replicon chromosome
Accession NZ_CP089165
Organism Staphylococcus aureus strain UNC_SaCF07

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag LTK18_RS03850 Protein ID WP_000074049.1
Coordinates 802987..803253 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag LTK18_RS03845 Protein ID WP_000587616.1
Coordinates 802730..802987 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LTK18_RS03830 (LTK18_03830) 799227..799976 - 750 WP_000072461.1 CPBP family lipoprotein N-acylation protein LnsB -
LTK18_RS03835 (LTK18_03835) 800171..801748 + 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
LTK18_RS03840 (LTK18_03840) 801916..802371 - 456 WP_000732076.1 DUF1307 domain-containing protein -
LTK18_RS03845 (LTK18_03845) 802730..802987 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LTK18_RS03850 (LTK18_03850) 802987..803253 + 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
LTK18_RS03855 (LTK18_03855) 803608..804684 + 1077 WP_001076673.1 M42 family metallopeptidase -
LTK18_RS03860 (LTK18_03860) 804932..805594 + 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
LTK18_RS03865 (LTK18_03865) 805587..806363 + 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
LTK18_RS03870 (LTK18_03870) 806759..807946 + 1188 WP_000026189.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T227788 WP_000074049.1 NZ_CP089165:802987-803253 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T227788 NZ_CP123040:363764-364111 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATTCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGAGCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT227788 WP_000587616.1 NZ_CP089165:802730-802987 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT227788 NZ_CP123040:364111-364410 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
AlphaFold DB W8TQT5

References