Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1399567..1400044 Replicon chromosome
Accession NZ_CP089162
Organism Staphylococcus aureus strain UNC_SaCF11

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag LTK16_RS07155 Protein ID WP_000052078.1
Coordinates 1399856..1400044 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag LTK16_RS07150 Protein ID WP_001059690.1
Coordinates 1399567..1399827 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LTK16_RS07115 (1394960) 1394960..1395676 - 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -
LTK16_RS07120 (1395824) 1395824..1396246 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
LTK16_RS07125 (1396645) 1396645..1397139 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
LTK16_RS07130 (1397294) 1397294..1397911 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
LTK16_RS07135 (1397984) 1397984..1398565 - 582 WP_001140686.1 histidine phosphatase family protein -
LTK16_RS07140 (1398790) 1398790..1399026 + 237 WP_000368687.1 hypothetical protein -
LTK16_RS07145 (1399023) 1399023..1399226 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
LTK16_RS07150 (1399567) 1399567..1399827 + 261 WP_001059690.1 hypothetical protein Antitoxin
LTK16_RS07155 (1399856) 1399856..1400044 + 189 WP_000052078.1 hypothetical protein Toxin
LTK16_RS07160 (1400232) 1400232..1400801 + 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
LTK16_RS07165 (1400889) 1400889..1401173 + 285 WP_001004395.1 hypothetical protein -
LTK16_RS07170 (1401235) 1401235..1401453 + 219 WP_000005886.1 hypothetical protein -
LTK16_RS07175 (1401949) 1401949..1402149 - 201 WP_001059082.1 cold-shock protein -
LTK16_RS07180 (1402506) 1402506..1403192 - 687 WP_001548082.1 thermonuclease family protein -
LTK16_RS07185 (1403533) 1403533..1404003 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(4-44)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T227783 WP_000052078.1 NZ_CP089162:1399856-1400044 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T227783 NZ_CP123037:c68603-68469 [Escherichia coli]
ATGACGAAATATACCCTTATCGGGTTGCTTGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACAGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT227783 WP_001059690.1 NZ_CP089162:1399567-1399827 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT227783 NZ_CP123037:68648-68708 [Escherichia coli]
TAAAGTGCATCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References